Role of twist in head and neck carcinoma with lymph node metastasis

Da Liang Ou, Hsiung Fei Chien, Chi Long Chen, Tsung Chin Lin, Liang In Lin

研究成果: 雜誌貢獻文章同行評審

54 引文 斯高帕斯(Scopus)


The transcription factor Twist protein has been found to be correlated with metastasis in various carcinomas, including hepatocellular, breast and prostate carcinomas. However, the role of Twist in head and neck squamous cell carcinomas (HNSCC) remains unknown. Head and neck cancer tissue microarrays (TMAs) of tumors from 50 patients with HNSCC were examined. Immunohistochemical (IHC) stain analysis showed that, out of the 50 patients, twenty (40%) showed Twist-positive staining in the tumor cells, and Twist expression was positively associated with differentiation status (p=0.027), lymph node metastasis (p=0.032) and disease progression (p=0.029). Further analysis revealed that the expression of Twist was positively correlated with CXCR4 (Spearman, r=0.408, p=0.003) and CCR7 (r=0.417, p=0.003). FindPatterns analysis suggested that the transcription factor Twist, as a basic helix-loop-helix (bHLH) protein, might regulate CXCR4 and CCR7 expression in squamous cell carcinomas, which in turn might be associated with lymph node metastasis.
頁(從 - 到)1355-1359
期刊Anticancer Research
發行號2 B
出版狀態已發佈 - 3月 2008

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科


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