Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2',3'-dideoxyinosine

Medicine & Life Sciences

• ribonucleotide reductase M2 100%
• Didanosine 79%
• Anti-HIV Agents 77%
• Hydroxyurea 67%
• HIV-1 48%
• DNA 25%
• HIV 19%
• S Phase 18%
• 2',3'-dideoxyadenosine triphosphate 18%
• Dideoxynucleosides 15%
• deoxyguanosine triphosphate 14%
• 2'-deoxycytidine 5'-triphosphate 14%
• thymidine 5'-triphosphate 13%
• Cell Cycle Resting Phase 11%
• triphosphoric acid 10%
• Messenger RNA 10%
• G1 Phase 9%
• Complementary DNA 7%
• Cell Cycle 7%
• Pharmaceutical Preparations 3%

Chemical Compounds

• Anti-HIV-1 Agent 93%
• Hydroxyurea 81%
• Ribonucleotide 69%
• dATP 47%
• dGTP 16%
• dCTP 16%
• dTTP 16%
• Complementary DNA 11%
• Mammalian Cell 11%
• Drug 5%