Role of inward rectifier potassium current on drug therapy of atrial fibrillation

Cheng Jeng Tai, Wen Hung Chao, Shih ann Chen, John K J Li, Po Min Chen, Jui chien Hsieh

研究成果: 雜誌貢獻文章同行評審

摘要

An S1-S2 stimulus protocol was used to test membrane threshold and subthreshold inactivation in relationship to prematurity and the conductance of IK1 (gk1). Results indicated that (1) required charge threshold for S2 was exponentially related to gk1 regardless of coupling interval both of normal and of fibrillation-induced cells; and (2) peak of sodium currents initiated by S2 was parabolically related to baseline gk1 with 70% maximum sodium currents occurring at 33% reduced gk1 in the fibrillation induced model cell only.

原文英語
期刊Annals of Biomedical Engineering
28
發行號SUPPL. 1
出版狀態已發佈 - 2000
對外發佈

ASJC Scopus subject areas

  • 生物醫學工程

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