TY - JOUR
T1 - Role of IL-17F in the pathogenesis of psoriasis
AU - Nakajima, Masayuki
AU - Kawaguchi, Mio
AU - Watanabe, Hideaki
AU - Morishima, Yuko
AU - Huang, Shau Ku
AU - Satoh, Hiroaki
AU - Hizawa, Nobuyuki
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Psoriasis is a complex autoimmune inflammatory disease with a genetic basis. The increased expression of IL-17F gene and protein is observed in the lesional skins of psoriatic patients. We and other groups discovered human IL-17F gene that shows the highest homology with IL-17A. IL-17F induces various inflammatory molecules, such as IL-6 and IL-8. IL-17F is mainly derived from Th17, Tc17 and ILC3 cells, and induces CCL20 expression, resulting in the recruitment of additional IL-17F-producing cells to enhance skin inflammation via CCR6. The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and several signaling pathways have been identified. Injection with IL-17F in mice revealed marked neutrophilia in dermis, and its infiltration was significantly inhibited by anti-IL-8 antibody. Sequence variants of the IL-17F gene are associated with response to treatments, and a variant (rs763780) of IL-17F encodes an antagonist for the wild-type IL-17F. Hence, IL-17F may play a pivotal role in the pathogenesis of psoriasis, and may provide a promising therapeutic target for development of novel strategies.
AB - Psoriasis is a complex autoimmune inflammatory disease with a genetic basis. The increased expression of IL-17F gene and protein is observed in the lesional skins of psoriatic patients. We and other groups discovered human IL-17F gene that shows the highest homology with IL-17A. IL-17F induces various inflammatory molecules, such as IL-6 and IL-8. IL-17F is mainly derived from Th17, Tc17 and ILC3 cells, and induces CCL20 expression, resulting in the recruitment of additional IL-17F-producing cells to enhance skin inflammation via CCR6. The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and several signaling pathways have been identified. Injection with IL-17F in mice revealed marked neutrophilia in dermis, and its infiltration was significantly inhibited by anti-IL-8 antibody. Sequence variants of the IL-17F gene are associated with response to treatments, and a variant (rs763780) of IL-17F encodes an antagonist for the wild-type IL-17F. Hence, IL-17F may play a pivotal role in the pathogenesis of psoriasis, and may provide a promising therapeutic target for development of novel strategies.
KW - IL-17 cytokine family
KW - IL-17F
KW - Psoriasis
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U2 - 10.2174/1573395513666161214121923
DO - 10.2174/1573395513666161214121923
M3 - Review article
AN - SCOPUS:85011012898
SN - 1573-3955
VL - 12
SP - 112
EP - 117
JO - Current Immunology Reviews
JF - Current Immunology Reviews
IS - 2
ER -