Role of creatine phosphokinase in predicting acute renal failure in hypocalcemic exertional heat stroke

Shang Der Shieh, Yuh Feng Lin, Kuo Cheng Lu, Bi Lian Li, Pauling Chu, Tai Pin Shyh, Liang Kuang Diang

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)


Recruits frequently develop hypocalcemia in exertional heat stroke (ExHS) with rhabdomyolysis and acute renal failure (ARF) from intensive training. It usually indicated severe skeletal muscle damage. However, the relative risk of ARF in ExHS patients complicated with hypocalcemia was unknown. The present study was undertaken to evaluate the value of peak serum creatine phosphokinase (CPK) level in predicting ARF in ExHS patients with hypocalcemia. Sixty-eight army recruits with ExHS were hospitalized at the Tri-Service General Hospital, Taiwan: 17 with ARF and hypocalcemia (group A); 7 with ARF but without hypocalcemia (group B); 20 without ARF but with hypocalcemia (group C); and 24 without ARF or hypocalcemia (group D). In the 24 patients with ARF (groups A and B) the serum phosphate and peak CPK levels were significantly higher than in patients without ARF (groups C and D; p <0.001), serum calcium levels were also significantly lower in the former (p <0.001). In the 37 patients with hypocalcemia (groups A and C), the peak serum CPK levels were significantly higher than in those without hypocalcemia (groups B and D; p <0.001). There was a higher proportion of hypocalcemic patients with peak serum CPK levels greater than 10, 000 U/l among ARF compared with patients without ARF (χ2 = 12.48, p <0.001). In 24 patients with ARF, there was a negative correlation between serum Ca and peak CPK levels (t = 3.37, r = -0.58, p <0.01). However, a positive correlation was found between serum creatinine and peak serum CPK levels in 37 patients with hypocalcemia (t = 2.47, r = 0.39, p <0.02). In conclusion, hypocalcemia was found in 37/68 (54.4%) of ExHS patients. Peak serum CPK over 10, 000 U/l increases the tendency of developing ARF; furthermore, it is unequivocally useful in predicting ARF in hypocalcemic ExHS patients.

頁(從 - 到)252-258
期刊American Journal of Nephrology
出版狀態已發佈 - 1992

ASJC Scopus subject areas

  • 腎臟病學


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