Risk of type 2 diabetes mellitus in patients with acute critical illness: a population-based cohort study

Chin Wang Hsu, Chin Sheng Lin, Sy Jou Chen, Shih Hua Lin, Cheng Li Lin, Chia Hung Kao

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)


Purpose: This large population-based cohort study evaluated the association between certain critical illnesses and the incidence of newly diagnosed type 2 diabetes mellitus (T2DM) in Taiwan. Methods: Data were obtained from the Taiwan National Health Insurance Research Database. According to age, sex, and propensity score-matching, a cohort comprising 9528 patients with critical illness, including septicemia, septic shock, acute myocardial infarction (AMI), and stroke, and a control cohort of 9528 patients with no critical illness were identified. Cox proportional-hazard regression and competing-risk regression models were employed to evaluate the risk of developing T2DM. Findings: With the median follow-up periods (interquartile range) of 3.86 (1.64–6.93) and 5.12 (2.51–8.13) years for the patients in the critical illness and control cohorts, respectively, the risk of developing T2DM in the critical illness cohort was significantly higher than in the control cohort (adjusted hazard ratio, aHR = 1.32; 95 % confidence interval, CI 1.16–1.50). In the multivariate competing-risk regression models, the aHR of T2DM was 1.58 (95 % CI 1.45–1.72) in the critical illness cohort. Moreover, among the patients with these critical illnesses, those with septicemia or septic shock exhibited the highest risk of developing T2DM (aHR = 1.51, 95 % CI 1.37–1.67), followed by AMI compared with the control cohort. Conclusion: Our results suggest that patients with certain critical illnesses are associated with a high risk of developing T2DM. Clinicians should be aware of this association and intensively screen for T2DM in patients following diagnosis of critical illness.

頁(從 - 到)38-45
期刊Intensive Care Medicine
出版狀態已發佈 - 1月 1 2016

ASJC Scopus subject areas

  • 重症監護和重症監護醫學


深入研究「Risk of type 2 diabetes mellitus in patients with acute critical illness: a population-based cohort study」主題。共同形成了獨特的指紋。