Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study

Chao Yueh Fan, Chun Shu Lin, Hsing Lung Chao, Wen Yen Huang, Yu Fu Su, Kuen Tze Lin, I. J. Tsai, Chia Hung Kao

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

Background and purpose This study aimed to assess the incidence and risk of hypothyroidism among patients with nasopharyngeal carcinoma (NPC) after radiation therapy (RT). Material and methods We identified 14,893 NPC patients and 16,105 other head and neck cancer (HNC) patients treated with RT without thyroidectomy from the National Health Insurance Research Database in Taiwan between 2000 and 2011. Each NPC patient was randomly frequency-matched with four individuals without NPC by age, sex, and index year. Competing-risk regression models were used to estimate hazard ratios (HRs) of hypothyroidism requiring thyroxin associated with NPC after RT. Results The risk of developing hypothyroidism was significantly higher in the NPC cohort than in the matched cohort (adjusted HR = 14.35, 95% CI = 11.85–17.37) and the HNC cohort (adjusted HR = 2.06, 95% CI = 1.69–2.52). Independent risk factors for hypothyroidism among NPC patients included younger age, female sex, higher urbanization level, autoimmune disease, and receipt of chemotherapy. Conclusion The risk of hypothyroidism requiring thyroxin was significantly higher in NPC patients after RT than in the general Taiwanese population and HNC patients. Regular clinical and serum thyroid function tests are essential among NPC survivors after RT.
原文英語
頁(從 - 到)394-400
頁數7
期刊Radiotherapy and Oncology
123
發行號3
DOIs
出版狀態已發佈 - 6月 2017
對外發佈

ASJC Scopus subject areas

  • 血液學
  • 腫瘤科
  • 放射學、核子醫學和影像學

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