TY - JOUR
T1 - Risk of dementia in patients with periodontitis and related protective factors
T2 - A nationwide retrospective cohort study
AU - Lee, Chia Yen
AU - Chang, Chuen Chau
AU - Lin, Chao Shun
AU - Yeh, Chun Chieh
AU - Hu, Chaur Jong
AU - Wu, Ching Zong
AU - Chen, Ta Liang
AU - Liao, Chien Chang
N1 - Funding Information:
This study was supported in part by The Higher Education Sprout Project by the Ministry of Education (DP2‐109‐21121‐01‐N‐08‐04) and Taiwan's Ministry of Science and Technology (MOST108‐2221‐E‐038‐006 and MOST106‐2314‐B‐038‐036‐MY3).
Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Aim: We aimed to evaluate the long-term risk of dementia in patients with periodontitis and its associated factors. Materials and Methods: Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions. Results: Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67–1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71–0.87), metformin (HR: 0.53, 95% CI: 0.44–0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61–0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors. Conclusions: Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.
AB - Aim: We aimed to evaluate the long-term risk of dementia in patients with periodontitis and its associated factors. Materials and Methods: Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions. Results: Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67–1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71–0.87), metformin (HR: 0.53, 95% CI: 0.44–0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61–0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors. Conclusions: Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.
KW - dementia
KW - influenza vaccination
KW - metformin
KW - periodontitis
KW - statins
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U2 - 10.1111/jcpe.13372
DO - 10.1111/jcpe.13372
M3 - Article
C2 - 32991015
AN - SCOPUS:85096580587
SN - 0303-6979
VL - 47
SP - 1428
EP - 1436
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 12
ER -
