TY - JOUR
T1 - Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01-AE and subtype B
AU - Oyomopito, Rebecca A.
AU - Chen, Yen Ju
AU - Sungkanuparph, Somnuek
AU - Kantor, Rami
AU - Merati, Tuti
AU - Yam, Wing Cheong
AU - Sirisanthana, Thira
AU - Li, Patrick C.K.
AU - Kantipong, Pacharee
AU - Phanuphak, Praphan
AU - Lee, Chris K.C.
AU - Kamarulzaman, Adeeba
AU - Ditangco, Rossana
AU - Huang, Szu Wei
AU - Sohn, Annette H.
AU - Law, Matthew
AU - Chen, Yi Ming A.
N1 - Funding Information:
The TREAT Asia HIV Observational Database, TREAT Asia Studies to Evaluate Resistance, and the Australian HIV Observational Database are initiatives of TREAT Asia, a program of amfAR, The Foundation for AIDS Research, with support from the Dutch Ministry of Foreign Affairs through a partnership with Stichting Aids Fonds, and the U.S. National Institutes of Health's National Institute of Allergy and Infectious Diseases , Eunice Kennedy Shriver National Institute of Child Health and Human Development , and National Cancer Institute , as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA; U01AI069907 ). Queen Elizabeth Hospital and the Integrated Treatment Centre received additional support from the Hong Kong Council for AIDS Trust Fund . The Kirby Institute is funded by the Australian Government Department of Health and Ageing , and is affiliated with the Faculty of Medicine, University of New South Wales. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above.
Publisher Copyright:
© 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Human immunodeficiency virus (HIV)-1 epidemics in Asian countries are driven by varying exposures. The epidemiology of the regional pandemic has been changing with the spread of HIV-1 to lower-risk populations through sexual transmission. Common HIV-1 genotypes include subtype B and circulating recombinant form (CRF) 01-AE. Our objective was to use HIV-1 genotypic data to better quantify local epidemics. TASER-M is a multicenter prospective cohort of HIV-infected patients. Associations between HIV exposure, patient sex, country of sample origin and HIV-1 genotype were evaluated by multivariate logistic regression. Phylogenetic methods were used on genotypic data to investigate transmission relationships. A total of 1086 patients from Thailand, Hong Kong, Malaysia and the Philippines were included in analyses. Proportions of male patients within countries varied (Thailand: 55.6%, Hong Kong: 86.1%, Malaysia: 81.4%, Philippines: 93.8%; p < 0.001) as did HIV exposures (heterosexual contact: Thailand: 85.7%, Hong Kong, 46.2%, Malaysia: 47.8%, Philippines: 25.0%; p < 0.001). After adjustment, we found increased subtype B infection among men who have sex with men, relative to heterosexual-reported exposures (odds ratio = 2.4, p < 0.001). We further describe four transmission clusters of eight to 15 treatment naïve, predominantly symptomatic patients (two each for subtype B and CRF01-AE). Risk-group subpopulations differed with respect to the infecting HIV-1 genotype. Homosexual exposure patients had higher odds of being infected with subtype B. Where HIV-1 genotypes circulate within countries or patient risk-groups, local monitoring of genotype-specific transmissions may play a role in focusing public health prevention strategies. Phylogenetic evaluations provide complementary information for surveillance and monitoring of viruses with high mutation rates such as HIV-1 and Ebola.
AB - Human immunodeficiency virus (HIV)-1 epidemics in Asian countries are driven by varying exposures. The epidemiology of the regional pandemic has been changing with the spread of HIV-1 to lower-risk populations through sexual transmission. Common HIV-1 genotypes include subtype B and circulating recombinant form (CRF) 01-AE. Our objective was to use HIV-1 genotypic data to better quantify local epidemics. TASER-M is a multicenter prospective cohort of HIV-infected patients. Associations between HIV exposure, patient sex, country of sample origin and HIV-1 genotype were evaluated by multivariate logistic regression. Phylogenetic methods were used on genotypic data to investigate transmission relationships. A total of 1086 patients from Thailand, Hong Kong, Malaysia and the Philippines were included in analyses. Proportions of male patients within countries varied (Thailand: 55.6%, Hong Kong: 86.1%, Malaysia: 81.4%, Philippines: 93.8%; p < 0.001) as did HIV exposures (heterosexual contact: Thailand: 85.7%, Hong Kong, 46.2%, Malaysia: 47.8%, Philippines: 25.0%; p < 0.001). After adjustment, we found increased subtype B infection among men who have sex with men, relative to heterosexual-reported exposures (odds ratio = 2.4, p < 0.001). We further describe four transmission clusters of eight to 15 treatment naïve, predominantly symptomatic patients (two each for subtype B and CRF01-AE). Risk-group subpopulations differed with respect to the infecting HIV-1 genotype. Homosexual exposure patients had higher odds of being infected with subtype B. Where HIV-1 genotypes circulate within countries or patient risk-groups, local monitoring of genotype-specific transmissions may play a role in focusing public health prevention strategies. Phylogenetic evaluations provide complementary information for surveillance and monitoring of viruses with high mutation rates such as HIV-1 and Ebola.
KW - Asia
KW - CRF01-AE
KW - HIV exposure
KW - Subtype B
UR - http://www.scopus.com/inward/record.url?scp=84941077211&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941077211&partnerID=8YFLogxK
U2 - 10.1016/j.kjms.2015.07.002
DO - 10.1016/j.kjms.2015.07.002
M3 - Article
C2 - 26362956
AN - SCOPUS:84941077211
SN - 1607-551X
VL - 31
SP - 445
EP - 453
JO - Kaohsiung Journal of Medical Sciences
JF - Kaohsiung Journal of Medical Sciences
IS - 9
ER -
