Risk factors for early cardiovascular mortality in patients with bipolar disorder

Shang Ying Tsai, Chao Hsien Lee, Pao Huan Chen, Kuo Hsuan Chung, Shou Hung Huang, Chian Jue Kuo, Cheng Wen Wu

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)


Aim: We attempted to determine risk factors, particularly pathophysiological changes, for early cardiovascular mortality in bipolar disorder (BD). Methods: A total of 5416 inpatients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD; ICD 9: 401-443) before the age of 65years were identified. Two living BD patients and two mentally healthy adults were matched with each deceased patient as control subjects according to age (±2years), sex, and date (±3years) of the final/index admission or the date of general health screening. Data were obtained through medical record reviews. Results: Eighty percent of CVD deaths occurred within 10years following the index admission. Conditional logistic regression revealed that the variables most strongly associated with CVD mortality were the leukocyte count and heart rate on the first day of the index hospitalization, as the deceased BD patients were compared with the living BD controls. Systolic pressure on the first day of the index hospitalization can be substituted for heart rate as another risk factor for CVD mortality. Conclusion: It is suggested that systemic inflammation and sympathetic overactivity during the acute phase of BD may be risk factors for early CVD mortality.
頁(從 - 到)716-724
期刊Psychiatry and Clinical Neurosciences
出版狀態已發佈 - 10月 2017

ASJC Scopus subject areas

  • 神經科學 (全部)
  • 神經內科
  • 神經病學(臨床)
  • 精神病學和心理健康


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