@article{e623005e06874987bf72377220fcb952,
title = "Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency",
abstract = "The synthesis of a 24-membered macrocyclic hexaoxazole via ring-closing metathesis is described. The target compound selectively stabilizes G-quadruplex DNA with no detectable stabilization of duplex DNA. An MTT cytotoxicity assay indicated that this unsaturated macrocyclic hexaoxazole exhibits significant cytotoxicity toward P388, RPMI 8402, and KB3-1 cell lines with IC50 values of 45, 25, and 38 nM, respectively.",
keywords = "Cytotoxic, G-quadruplex stabilizer, Hexaoxazole, Macrocycle, Ring-closing metathesis, Selective, Synthesis",
author = "Mavurapu Satyanarayana and Rzuczek, {Suzanne G.} and LaVoie, {Edmond J.} and Pilch, {Daniel S.} and Angela Liu and Liu, {Leroy F.} and Rice, {Joseph E.}",
note = "Funding Information: This study was supported by generous funding from Celgene Corp. and NIH Grants CA098127 (E.J.L.) and CA097123 (D.S.P.). Mass spectrometry was provided by the Washington University Mass Spectrometry Resource with support from the NIH National Center for Research Resources Grant P41RR0954.",
year = "2008",
month = jul,
day = "1",
doi = "10.1016/j.bmcl.2008.05.032",
language = "English",
volume = "18",
pages = "3802--3804",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ireland Ltd",
number = "13",
}