RIFLE classification can predict short-term prognosis in critically ill cirrhotic patients

Chang Chyi Jenq, Ming Hung Tsai, Ya Chung Tian, Chan Yu Lin, Chun Yang, Nai Jen Liu, Jau Min Lien, Yung Chang Chen, Ji Tseng Fang, Pan Chi Chen, Chih Wei Yang

研究成果: 雜誌貢獻文章同行評審

100 引文 斯高帕斯(Scopus)


Objective: End-stage liver disease is frequently complicated by renal function disturbances. Cirrhotic patients with renal failure admitted to intensive care units (ICUs) have high mortality rates. This study analyzed the outcomes of critically ill cirrhotic patients and identified the association between prognosis and RIFLE (risk of renal failure, injury to kidney, failure of kidney function, loss of kidney function, and end-stage renal failure) classification, in comparison with other five scoring systems. Design: Prospective, clinical study. Setting: Ten-bed specialized hepatogastroenterology ICU in a university hospital in Taiwan. Patients and participants: One hundred and thirty-four cirrhotic patients consecutively admitted to ICU during a 1.5-year period. Interventions: Thirty-two demographic, clinical and laboratory variables were analyzed as predictors of survival. Measurements and main results: Overall hospital mortality was 65.7%. There was a progressive and significant increase (χ2 for trend: p < 0.001) in mortality based on RIFLE classification severity. Multiple logistic regression analysis indicated that RIFLE classification and Sequential Organ Failure Assessment (SOFA) score on the first day of ICU admission were independent risk factors for hospital mortality. By using the areas under the receiver operating characteristic curve (AUROC), the RIFLE category and SOFA both indicated a good discriminative power (AUROC 0.837 ± 0.036 and 0.917 ± 0.025; p < 0.001). Cumulative survival rates at 6-month follow-up differed significantly (p < 0.05) for non-ARF vs. RIFLE-R, RIFLE-I, and RIFLE-F. Conclusion: Both SOFA and RIFLE category showed high discriminative power in predicting hospital mortality in critically ill patients with cirrhosis. The RIFLE classification is a simple and easily applied evaluative tool with good prognostic abilities.

頁(從 - 到)1921-1930
期刊Intensive Care Medicine
出版狀態已發佈 - 11月 2007

ASJC Scopus subject areas

  • 重症監護和重症監護醫學


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