Rhodiola rosea ne réduit pas l'activité inflammatoire in vivo après un exercice d'endurance continu

Introduction: It is believed that Rhodiola rosea is able to reduce various stressors caused by chemical and biological factors. Studies have demonstrated that Rhodiola rosea is able to retard muscle damage caused by intense exercise; however, whether this effect is related to inflammatory cytokines remains unknown. The purpose of this study is to examine the impact of Rhodiola rosea administration after continuous endurance exercise on the inflammatory responses. Summary of facts and results: Twelve healthy subjects were recruited. The study was a randomized, double-blind, crossover study, composed of two 8-day trials, each separated by a 2-week washout phase. Each trial included a 3-day exercise period consisting of a 30-min run at 75% VO 2 max per day followed by a 5-day recovery period. The subjects were given two orally administered capsules of placebo (P) or Rhodiola rosea (Rh) per day during the recovery period and immediately after continuous exercise. At 24 and 48 h after the exercise, the blood creatine kinase (CK) levels were higher than those before exercise in both groups. The blood variables had returned to the baseline level at 24 h after exercise except the CK level. The CK levels were lower in the Rh group than that in the P group 72 h after continuous exercise (208.2 ± 32.7 vs 136.7 ± 13.8 U/L, P < .05). However, there was no significant difference in other blood variables between groups. Conclusion: The main finding of this study is that supplementation of Rhodiola rosea after continuous endurance exercise has a trend to decrease blood CK levels moderately, but it is unable to reduce inflammatory reactions.