Retinal ganglion cell–inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly

Yao Lin Liu, Yi Ting Hsieh, Ta Fu Chen, Jeng Min Chiou, Min Kuang Tsai, Jen Hau Chen, Yen Ching Chen

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

Introduction: Thinning of optical coherence tomography–measured retinal nerve fiber layer thickness and ganglion cell–inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear. Methods: This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition. Results: The performance of global cognition decreased as mean GC-IPL of bilateral eyes deviated from the sample mean (77.5 μm) (quadratic GC-IPL: β = –0.49 × 10−2; 95% confidence interval: −0.74 × 10−2 to −0.23 × 10−2). Similar associations were also found for logical memory. No significant association was observed between retinal nerve fiber layer and cognition. Discussion: Either thinning or thickening of GC-IPL was associated with poor cognition in nondemented elderly (a U-shaped association). GC-IPL may serve as a noninvasive preclinical predictor of Alzheimer's disease.
原文英語
頁(從 - 到)19-27
頁數9
期刊Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
11
DOIs
出版狀態已發佈 - 12月 2019
對外發佈

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 精神病學和心理健康

指紋

深入研究「Retinal ganglion cell–inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly」主題。共同形成了獨特的指紋。

引用此