摘要
Introduction: Thinning of optical coherence tomography–measured retinal nerve fiber layer thickness and ganglion cell–inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear. Methods: This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition. Results: The performance of global cognition decreased as mean GC-IPL of bilateral eyes deviated from the sample mean (77.5 μm) (quadratic GC-IPL: β = –0.49 × 10−2; 95% confidence interval: −0.74 × 10−2 to −0.23 × 10−2). Similar associations were also found for logical memory. No significant association was observed between retinal nerve fiber layer and cognition. Discussion: Either thinning or thickening of GC-IPL was associated with poor cognition in nondemented elderly (a U-shaped association). GC-IPL may serve as a noninvasive preclinical predictor of Alzheimer's disease.
原文 | 英語 |
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頁(從 - 到) | 19-27 |
頁數 | 9 |
期刊 | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
卷 | 11 |
DOIs | |
出版狀態 | 已發佈 - 12月 2019 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 神經病學(臨床)
- 精神病學和心理健康