Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo

An Sheng Cheng, Yu Hsiang Cheng, Chi Ying Lee, Chin Yuan Chung, Wen Chang Chang

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)


Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.
頁(從 - 到)2850-2865
出版狀態已發佈 - 4月 15 2015

ASJC Scopus subject areas

  • 食品科學
  • 營養與營養學


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