Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya Chen Ko; Chia Ling Chang; Hsiung-Fei Chien; Ching-Hsiang Wu; Liang In Lin

doi:10.1016/j.canlet.2011.05.014

Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya Chen Ko, Chia Ling Chang, Hsiung-Fei Chien, Ching-Hsiang Wu, Liang In Lin

研究成果: 雜誌貢獻 › 文章 › 同行評審

31 引文斯高帕斯（Scopus）

摘要

Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

原文	英語
頁（從 - 到）	46-53
頁數	8
期刊	Cancer Letters
卷	309
發行號	1
DOIs	https://doi.org/10.1016/j.canlet.2011.05.014
出版狀態	已發佈 - 10月 1 2011
對外發佈	是

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癌症研究

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title = "Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells",

abstract = "Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.",

keywords = "Anaplastic large-cell lymphoma, Apoptosis, Differentiation, Fas/CD95, Resveratrol, SR-786",

author = "Ko, {Ya Chen} and Chang, {Chia Ling} and Hsiung-Fei Chien and Ching-Hsiang Wu and Lin, {Liang In}",

note = "Funding Information: This work was supported by research grants from the National Science Council (NSC 98-2622-8-002-006-A2 and 98-2120-M-002-009), Taiwan.",

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AU - Ko, Ya Chen

AU - Chang, Chia Ling

AU - Chien, Hsiung-Fei

AU - Wu, Ching-Hsiang

AU - Lin, Liang In

N1 - Funding Information: This work was supported by research grants from the National Science Council (NSC 98-2622-8-002-006-A2 and 98-2120-M-002-009), Taiwan.

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

AB - Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

KW - Anaplastic large-cell lymphoma

KW - Apoptosis

KW - Differentiation

KW - Fas/CD95

KW - Resveratrol

KW - SR-786

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Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

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