TY - JOUR
T1 - Restriction fragment length polymorphism analysis to study the genetic origin of complete hydatidiform mole
AU - Ko, Tsang Ming
AU - Hsieh, Chang Yao
AU - Ho, Hong Nerng
AU - Hsieh, Fon Jou
AU - Lee, Tzu Yao
PY - 1991/1/1
Y1 - 1991/1/1
N2 - To determine the genetic origin of the complete hydatidiform mole, 20 abnormal pregnancies were studied with restriction fragment length polymorphism with five genomic probes: EJ 6.6, β-globin gene, 3′α-hypervariable region, J-Bir, and St14. In the 12 cases of molar pregnancy, pure paternal origin was proved in 11 cases, but both maternal and paternal inheritance were shown in only one case. In the cases with pure paternal origin, all of the restriction fragment length polymorphisms were homozygous, although those of the fathers were heterozygous at 15 loci. In the four cases that mimicked hydatidiform mole but were diagnosed as hydropic change of villi, both paternal and maternal inheritance were noted. In the four pregnancies with blighted ovum, both paternal and maternal inheritance were shown in three cases; and in one case with a balanced translocation between chromosomes 13 and 14, only paternal inheritance was noted. This study showed that most of the complete hydatidiform moles were caused by fertilization of an empty egg by a duplicated haploid sperm, but rare exceptions may exist.
AB - To determine the genetic origin of the complete hydatidiform mole, 20 abnormal pregnancies were studied with restriction fragment length polymorphism with five genomic probes: EJ 6.6, β-globin gene, 3′α-hypervariable region, J-Bir, and St14. In the 12 cases of molar pregnancy, pure paternal origin was proved in 11 cases, but both maternal and paternal inheritance were shown in only one case. In the cases with pure paternal origin, all of the restriction fragment length polymorphisms were homozygous, although those of the fathers were heterozygous at 15 loci. In the four cases that mimicked hydatidiform mole but were diagnosed as hydropic change of villi, both paternal and maternal inheritance were noted. In the four pregnancies with blighted ovum, both paternal and maternal inheritance were shown in three cases; and in one case with a balanced translocation between chromosomes 13 and 14, only paternal inheritance was noted. This study showed that most of the complete hydatidiform moles were caused by fertilization of an empty egg by a duplicated haploid sperm, but rare exceptions may exist.
KW - Complete hydatidiform mole
KW - genetic origin
KW - restriction fragment length polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0025964424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025964424&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(91)90537-2
DO - 10.1016/0002-9378(91)90537-2
M3 - Article
C2 - 1672240
AN - SCOPUS:0025964424
SN - 0002-9378
VL - 164
SP - 901
EP - 906
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 3
ER -