Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

Seng Wong Huang, Kok Min Seow, Low Tone Ho, Yueh Chien, Dong Yue Chung, Chih Ling Chang, Ying Hsiu Lai, Jiann Loung Hwang, Chi Chang Juan

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48 引文 斯高帕斯(Scopus)


Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes. The aim of this study was to evaluate the regulatory effect of estrogen on adipocyte resistin gene expression in ovariectomized (OVX) rats and in isolated rat adipocytes in vitro. Subcutaneous injection of estradiol benzoate reduced resistin mRNA levels in adipocytes isolated from the inguinal, parametrial, perirenal, retroperitoneal, or periovarian fat deposits of OVX rats, while an in vitro study showed that estradiol treatment decreased resistin mRNA levels in cultured rat periovarian fat adipocytes. Results of Western blotting analysis also showed that estrogen decreased adipose resistin contents in vivo and in vitro. These data suggest that estrogen is a pivotal negative regulator of resistin gene expression.
頁(從 - 到)449-454
期刊FEBS Letters
出版狀態已發佈 - 1月 17 2005

ASJC Scopus subject areas

  • 生物化學
  • 生物物理學
  • 分子生物學


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