@article{827d287ae04f4ac89a8ceaa4122f05e5,
title = "Renal insufficiency plays a crucial association factor in severe knee osteoarthritis-induced pain in patients with total knee replacement: A retrospective study",
abstract = "Pain, the main symptom of osteoarthritis (OA), can lead to functional disability in patients with knee OA. Understanding the association factors related to knee pain is important since preventing OA-induced disabilities can be achieved by modifying these pain-associated issues. Therefore, this study was aimed to investigate the association factors for OA-induced knee pain in Taiwanese patients who received total knee replacements (TKR).In this retrospective study, 357 subjects who had undergone TKR at the Taipei Municipal Wan-Fang Hospital were recruited. The distribution of pain severity among patients with knee OA was evaluated. Demographic data and clinical parameters were analyzed to determine relationships between these variables and the severity of knee OA pain.Of the 357 patients studied, 54% and 33% had moderate and severe knee pain, respectively. Furthermore, a multivariate logistic regression analysis revealed that serum creatinine (>1.5mg/dL) and an estimated glomerular filtration rate (EGFR) (<60mL/min/1.73 m2) were significantly associated with severe knee pain in OA patients. A significant correlation between severe knee pain and serum creatinine or EGFR was demonstrated by Pearson correlations.Taken together, the renal insufficiency defined by an elevated serum creatinine or a low EGFR in OA patients who required TKR was associated with severe knee pain. These variables must be considered while treating knee OA pain, especially in those patients with severe pain.",
keywords = "estimated glomerular filtration rate, osteoarthritis, renal insufficiency, serum creatinine, severe knee pain, Arthroplasty, Replacement, Knee/adverse effects, Glomerular Filtration Rate, Humans, Male, Creatinine/blood, Osteoarthritis, Knee/complications, Renal Insufficiency/complications, Arthralgia/etiology, Female, Aged, Retrospective Studies, Pain Measurement",
author = "Chio, {Chung Ching} and Siu, {Man Kit} and Tai, {Yu Ting} and Chen, {Tyng Guey} and Ho, {Wei Pin} and Chen, {Jui Tai} and Tsai, {Hsiao Chien} and Chen, {Ruei Ming}",
note = "Funding Information: This study was supported by grants from the Chi-Mei Medical Center (105CM-TMU-16-1 and 108CM-TMU-16-1), Wan-Fang Hospital (102wf-eva-10 and 102-wf-eva-13), and “TMU Research Center of Cancer Translational Medicine” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE), Taipei, Taiwan. The authors have no conflicts of interest to disclose. aDepartment of Neurosurgery, Chi Mei Medical Center, Tainan, bCell Physiology and Molecular Image Research Center, Wan Fang Hospital, cGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, dDepartment of Anesthesiology, Centro Hospitalar Conde de S{\'a}o Janu{\'a}rio, Macau Special Administrative Region, China, eDepartment of Anesthesiology, Wan-Fang Hospital, fDepartment of Anesthesiology, Shuang Ho Hospital, gAnesthesiology and Health Policy Research Center, Taipei Medical University Hospital, Taipei Medical University, hTMU Research Center of Cancer Translational Medicine, Taipei, Taiwan. ∗Correspondence: Ruei-Ming Chen, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Xing St., Taipei 11031, Taiwan (e-mail: rmchen@tmu.edu.tw). Copyright {\textcopyright} 2020 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite this article: Chio CC, Siu MK, Tai YT, Chen TG, Ho WP, Chen JT, Tsai HC, Chen RM. Renal insufficiency plays a crucial association factor in severe knee osteoarthritis-induced pain in patients with total knee replacement: A retrospective study. Medicine 2020;99:6(e19125). Received: 1 July 2019 / Received in final form: 30 November 2019 / Accepted: 11 January 2020 Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved.",
year = "2020",
month = jan,
day = "1",
doi = "10.1097/MD.0000000000019125",
language = "English",
volume = "99",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "6",
}