@article{3adeeeb352ed4ae3b4021e735651c477,
title = "Renal function-dependent associations of statins with outcomes of ischemic stroke",
abstract = "Aim: Chronic kidney disease (CKD) is associated with unfavorable outcomes in patients with ischemic stroke. One major metabolic derangement of CKD is dyslipidemia, which can be managed by statins. This study aimed to investigate whether the association of statins with post-stroke outcomes would be affected by renal function. Methods: We evaluated the association of statin therapy at discharge with 3-month outcomes according to the estimated glomerular filtration rate (eGFR) of 50,092 patients with acute ischemic stroke from the Taiwan Stroke Registry from August 2006 to May 2016. The outcomes were mortality, functional outcome as modified Rankin Scale (mRS), and recurrent ischemic stroke at 3 months after index stroke. Results: Statin therapy at discharge was associated with lower risks of mortality (adjusted hazard ratio [aHR], 0.41; 95% confidence interval [CI], 0.34 to 0.50) and unfavorable functional outcomes (mRS 3–5; aHR, 0.80; 95% CI, 0.76 to 0.84) in ischemic stroke patients. After stratification by eGFR, the lower risk of mortality associated with statins was limited to patients with an eGFR above 15 mL/min/1.73 m2. Using statins at discharge was correlated with a lower risk of unfavorable functional outcomes in patients with an eGFR of 60–89 mL/ min/1.73 m2. Statin therapy in patients with an eGFR of 60–89 mL/min/1.73 m2 may be associated with a higher risk of recurrent ischemic stroke compared with nonusers (aHR, 1.29; 95% CI, 1.07 to 1.57). Conclusions: In patients with acute ischemic stroke, the associations of statins with mortality and functional outcomes was dependent on eGFR.",
keywords = "Brain infarction, Dyslipidemia, Outcome, Renal function, Statins",
author = "{Taiwan Stroke Registry Investigators} and Yeh, {Shin Joe} and Tang, {Sung Chun} and Tsai, {Li Kai} and Chen, {Chih Hung} and Hsu, {Shih Pin} and Yu Sun and Lien, {Li Ming} and Wei, {Cheng Yu} and Lai, {Ta Chang} and Chen, {Po Lin} and Chen, {Chien Chung} and Huang, {Pai Hao} and Lin, {Ching Huang} and Liu, {Chung Hsiang} and Lin, {Huey Juan} and Hu, {Chaur Jong} and Lin, {Cheng Li} and Jeng, {Jiann Shing} and Hsu, {Chung Y.}",
note = "Funding Information: The present study was supported by the research laboratory of pediatrics, Children{\textquoteright}s Hospital of China Medical University (DMR-105-041), China Medical University Hospital (DMR-106-025 and DMR-107-026), Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004), Academia Sinica Taiwan Biobank, Stroke Biosignature Project (BM10601010036), Taiwan Clinical Trial Consortium for Stroke (MOST 106-2321-B-039-005), Tseng-Lien Lin Foundation (Taichung, Taiwan), Taiwan Brain Disease Foundation (Taipei, Taiwan), National Taiwan University Hospital (Taiwan) (107-M4016), and Katsuzo and Kiyo Aoshima Memorial Funds (Japan). Funding Information: The present study was supported by the research laboratory of pediatrics, Children?s Hospital of China Medical University (DMR-105-041), China Medical University Hospital (DMR-106-025 and DMR-107-026), Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004), Academia Sinica Taiwan Biobank, Stroke Biosignature Project (BM10601010036), Taiwan Clinical Trial Consor-tium for Stroke (MOST 106-2321-B-039-005), Tseng-Lien Lin Foundation (Taichung, Taiwan), Taiwan Brain Disease Foundation (Taipei, Taiwan), National Taiwan University Hospital (Taiwan) (107-M4016), and Katsuzo and Kiyo Aoshima Memorial Funds (Japan). Publisher Copyright: {\textcopyright} 2021 Japan Atherosclerosis Society.",
year = "2021",
doi = "10.5551/jat.55210",
language = "English",
volume = "28",
pages = "146--156",
journal = "Journal of Atherosclerosis and Thrombosis",
issn = "1340-3478",
publisher = "Japan Atherosclerosis Society",
number = "2",
}