TY - JOUR
T1 - Renal dysfunction is associated with lower odds of home discharge for patients with stroke
AU - Taiwan Stroke Registry Investigators
AU - Wang, I. Kuan
AU - Yu, Tung Min
AU - Yen, Tzung Hai
AU - Chiu, Lu Ting
AU - Lien, Li Ming
AU - Sun, Yu
AU - Wei, Cheng Yu
AU - Hsu, Kai Cheng
AU - Lai, Ping Chin
AU - Li, Chi Yuan
AU - Sung, Fung Chang
AU - Hsu, Chung Y.
N1 - Funding Information:
This study is supported in part by the Ministry of Health and Welfare, Taiwan under grant number MOHW109-TDU-B-212-114,004, China Medical University Hospital under grant number DMR 110-200, DMR-110-037 and DMR-109-175, Academia Sinica Stroke Biosignature Project under grant number BM10701010021, MOST Clinical Trial Consortium for Stroke under grant number MOST 107-2321-B-039-004, Tseng-Lien Lin Foundation, Taichung, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. The authors are grateful to Taiwan Stroke Registry investigators for participating in data collection, and the Health Data Science Center, and China Medical University Hospital for providing administrative, technical, and funding support.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Objectives: Studies on the association of estimated glomerular filtration rate (eGFR) levels with hospital discharge disposition after stroke are limited with inconsistent results. This study investigated the odds of home discharge with eGFR levels at admission for patients with stroke using the Taiwan Stroke Registry (TSR) data. Methods: From the TSR database, a total of 51,338 stroke patients from 2006 to 2015 were categorized into five groups based on eGFR levels at admission. The proportion of home discharge by the eGFR levels was calculated and logistic regression analysis was used to estimate the related odds ratio (OR) and 95% confidence interval. Results: Near 85% of stroke patients were discharged to home. The proportion of home discharges decreased as the eGFR level declined. Compared to patients with eGFR ≥90 mL/min/1.73 m2, the adjusted ORs of home discharge were 0.91, 0.85, 0.63, 0.56 for patients with eGFR 60–89, eGFR 30–59, eGFR 15–29, and eGFR < 15 mL/min/1.73 m2 or on dialysis, respectively, in a graded relationship. The trends were consistent in the ischemic stroke and hemorrhagic stroke patients. The areas under the receiver operating characteristic curve for all stroke patients, ischemic stroke patients, and hemorrhagic stroke patients were 0.801, 0799, 0.815, respectively. Conclusion: The odds of home discharge for stroke patients decreased with a significant independent graded association with declining eGFR levels. Renal function could predict home discharge after stroke.
AB - Objectives: Studies on the association of estimated glomerular filtration rate (eGFR) levels with hospital discharge disposition after stroke are limited with inconsistent results. This study investigated the odds of home discharge with eGFR levels at admission for patients with stroke using the Taiwan Stroke Registry (TSR) data. Methods: From the TSR database, a total of 51,338 stroke patients from 2006 to 2015 were categorized into five groups based on eGFR levels at admission. The proportion of home discharge by the eGFR levels was calculated and logistic regression analysis was used to estimate the related odds ratio (OR) and 95% confidence interval. Results: Near 85% of stroke patients were discharged to home. The proportion of home discharges decreased as the eGFR level declined. Compared to patients with eGFR ≥90 mL/min/1.73 m2, the adjusted ORs of home discharge were 0.91, 0.85, 0.63, 0.56 for patients with eGFR 60–89, eGFR 30–59, eGFR 15–29, and eGFR < 15 mL/min/1.73 m2 or on dialysis, respectively, in a graded relationship. The trends were consistent in the ischemic stroke and hemorrhagic stroke patients. The areas under the receiver operating characteristic curve for all stroke patients, ischemic stroke patients, and hemorrhagic stroke patients were 0.801, 0799, 0.815, respectively. Conclusion: The odds of home discharge for stroke patients decreased with a significant independent graded association with declining eGFR levels. Renal function could predict home discharge after stroke.
KW - Estimated glomerular filtration rate
KW - hospital discharge disposition
KW - renal function
KW - stroke
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U2 - 10.1080/00325481.2021.1964198
DO - 10.1080/00325481.2021.1964198
M3 - Article
C2 - 34351833
AN - SCOPUS:85113150791
SN - 0032-5481
VL - 133
SP - 865
EP - 872
JO - Postgraduate Medicine
JF - Postgraduate Medicine
IS - 8
ER -