TY - JOUR
T1 - REM sleep behavior disorder (RBD) in dementia with lewy bodies (DLB)
AU - Chan, Po Chi
AU - Lee, Hsun Hua
AU - Hong, Chien Tai
AU - Hu, Chaur Jong
AU - Wu, Dean
N1 - Publisher Copyright:
© 2018 Po-Chi Chan et al.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.
AB - Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.
KW - Cognitive Dysfunction/complications
KW - Dementia/complications
KW - Humans
KW - Lewy Body Disease/complications
KW - Parkinson Disease/complications
KW - REM Sleep Behavior Disorder/physiopathology
KW - Sleep Wake Disorders/complications
KW - Sleep, REM/physiology
UR - http://www.scopus.com/inward/record.url?scp=85055555795&partnerID=8YFLogxK
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U2 - 10.1155/2018/9421098
DO - 10.1155/2018/9421098
M3 - Review article
C2 - 30018672
AN - SCOPUS:85055555795
SN - 0953-4180
VL - 2018
JO - Behavioural Neurology
JF - Behavioural Neurology
M1 - 9421098
ER -