@article{2f19895f87a2416fb59faa45ff93329e,
title = "Relative efficacy of weight management, exercise, and combined treatment for muscle mass and physical sarcopenia indices in adults with overweight or obesity and osteoarthritis: A network meta-analysis of randomized controlled trials",
abstract = "Aging and osteoarthritis are associated with high risk of muscle mass loss, which leads to physical disability; this loss can be effectively alleviated by diet (DI) and exercise (ET) interventions. This study investigated the relative effects of different types of diet, exercise, and combined treatment (DI + ET) on muscle mass and functional outcomes in individuals with obesity and lower-limb osteoarthritis. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) examining the efficacy of DI, ET, and DI + ET in patients with obesity and lower-extremity osteoarthritis. The included RCTs were analyzed through network meta-analysis and risk-of-bias assessment. We finally included 34 RCTs with a median (range/total) Physiotherapy Evidence Database score of 6.5 (4–8/10). DI plus resistance ET, resistance ET alone, and aerobic ET alone were ranked as the most effective treatments for increasing muscle mass (standard mean difference (SMD) = 1.40), muscle strength (SMD = 1.93), and walking speed (SMD = 0.46). Our findings suggest that DI+ET is beneficial overall for muscle mass in overweight or obese adults with lower-limb osteoarthritis, especially those who are undergoing weight management.",
keywords = "Diet, Exercise training, Muscle mass, Osteoarthritis, Physical function, Sarcopenia, Overweight/complications, Follow-Up Studies, Sarcopenia/complications, Humans, Middle Aged, Muscle Strength/physiology, Organ Size, Exercise/physiology, Risk, Treatment Outcome, Osteoarthritis/complications, Randomized Controlled Trials as Topic, Muscle, Skeletal/pathology, Regression Analysis, Walking/physiology, Publication Bias, Adult, Aged",
author = "Chu, {Shu Fen} and Liou, {Tsan Hon} and Chen, {Hung Chou} and Huang, {Shih Wei} and Liao, {Chun De}",
note = "Funding Information: Funding: This study was funded by grants from the Ministry of Science and Technology, Taiwan (MOST 108-2314-B-038-102-MY3), and Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, Taiwan (grant no. 109TMU-SHH-13). The funding source played no role in the design, implementation, data analysis, interpretation, or reporting of the study. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official view of the funding sources. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jun,
doi = "10.3390/nu13061992",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}