Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Chia Chun Yu; Ching Ruey Hsieh; George Hsiao; Pi Yu Chen; Meng Lun Chang; Hwa Wen Yin; Zong-Huei Li; Ching Kuo Lee

doi:10.3390/molecules17022082

Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Chia Chun Yu, Ching Ruey Hsieh, George Hsiao, Pi Yu Chen, Meng Lun Chang, Hwa Wen Yin, Zong-Huei Li, Ching Kuo Lee

研究成果: 雜誌貢獻 › 文章 › 同行評審

19 引文斯高帕斯（Scopus）

摘要

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

原文	英語
頁（從 - 到）	2082-2090
頁數	9
期刊	Molecules
卷	17
發行號	2
DOIs	https://doi.org/10.3390/molecules17022082
出版狀態	已發佈 - 2月 2012

ASJC Scopus subject areas

藥物發現
分析化學
化學（雜項）
分子醫學
物理與理論化學
藥學科學
有機化學

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10.3390/molecules17022082

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title = "Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata",

abstract = "Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.",

keywords = "Abietane diterpene, Euphorbia formosana, HT-1080, MMP-2, -9",

author = "Yu, {Chia Chun} and Hsieh, {Ching Ruey} and George Hsiao and Chen, {Pi Yu} and Chang, {Meng Lun} and Yin, {Hwa Wen} and Zong-Huei Li and Lee, {Ching Kuo}",

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AU - Hsieh, Ching Ruey

AU - Hsiao, George

AU - Chen, Pi Yu

AU - Chang, Meng Lun

AU - Yin, Hwa Wen

AU - Li, Zong-Huei

AU - Lee, Ching Kuo

PY - 2012/2

Y1 - 2012/2

N2 - Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

AB - Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3, 14-dione (6). The structures of compounds 1-6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3-5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

KW - Abietane diterpene

KW - Euphorbia formosana

KW - HT-1080

KW - MMP-2, -9

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Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

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