Reduced negative BOLD responses in the default-mode network and increased self-focus in depression

Simone Grimm, Jutta Ernst, Peter Boesiger, Daniel Schuepbach, Heinz Boeker, Georg Northoff

研究成果: 雜誌貢獻文章同行評審

94 引文 斯高帕斯(Scopus)


Objectives. Functional imaging studies in major depressive disorder (MDD) indicate abnormal resting state neural activity and negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network (DMN). Methods. Since activity in DMN regions has been associated with self-relatedness, we investigated neural activity in these regions during self-related emotional judgement and passive picture viewing in 25 patients with MDD and 25 healthy controls in an event-related fMRI design. Results. Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. Neuroimaging results in MDD patients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. Unlike in healthy subjects, the anterior medial cortical NBRs were no longer parametrically modulated by the degree of self-relatedness in MDD patients. Conclusions. Our findings suggest that reduced NBRs in the anterior regions of the default-mode network may signify decoupling from self-relatedness in MDD patients with the consecutive abnormal increase of self-focus.
頁(從 - 到)627-637
期刊World Journal of Biological Psychiatry
出版狀態已發佈 - 12月 2011

ASJC Scopus subject areas

  • 生物精神病學
  • 精神病學和心理健康


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