TY - JOUR
T1 - Reduced expression of tocopherol-associated protein (TAP/Sec14L2) in human breast cancer.
AU - Wang, X.
AU - Ni, Jing
AU - Hsu, Chen Long
AU - Johnykutty, Sharlin
AU - Tang, Ping
AU - Ho, Yuan Soon
AU - Lee, Chia Hwa
AU - Yeh, Shuyuang
PY - 2009/12
Y1 - 2009/12
N2 - We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.
AB - We show that TAP/Sec14L2 had a high expression in normal/benign breast, prostate, and liver tissues as compared to lung, colon, and kidney. Its expression was downregulated in breast cancer cell lines shown by quantitative-PCR. Further, 57% of 141 human invasive breast carcinomas had no or markedly reduced TAP/Sec14L2 expression by immunohistochemical staining, and the rate increased to 80% in high grade invasive carcinomas (p <.01). This downregulation of TAP/Sec14L2 was also present in ductal carcinoma in situ (DCIS) associated with invasive carcinomas. These findings raise the possibility that TAP/Sec14L2 may serve as a tumor suppressor in breast carcinogenesis.
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M3 - Article
C2 - 19909011
SN - 0735-7907
VL - 27
SP - 971
EP - 977
JO - Cancer Investigation
JF - Cancer Investigation
IS - 10
ER -
