TY - JOUR
T1 - Rapid correction of metabolic acidosis in chronic renal failure
T2 - Effect on parathyroid hormone activity
AU - Lu, K. C.
AU - Shieh, S. D.
AU - Li, B. L.
AU - Chu, P.
AU - Jan, S. Y.
AU - Lin, Y. F.
PY - 1994
Y1 - 1994
N2 - To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.
AB - To investigate the effect of rapid correction of chronic metabolic acidosis on circulating intact parathyroid hormone (I-PTH) activity by free calcium clamp in chronic renal failure, 18 patients were enrolled in this study. Metabolic acidosis was corrected by continuous bicarbonate infusion while plasma ionized calcium was clamped at the preinfusion level throughout the entire procedure. The plasma pH, bicarbonate, total CO2, sodium, serum total calcium and 1,25(OH)2 vitamin D3 levels increased significantly while serum concentrations of I-PTH, alkaline phosphatase and albumin showed significant decreases after bicarbonate infusion. The plasma ionized calcium, potassium, serum magnesium and inorganic phosphorus levels showed no significant difference before and after bicarbonate infusion. These results demonstrate that rapid correction of metabolic acidosis attenuates circulating PTH activity in chronic renal failure and may underline the importance of maintaining normal acid-base homeostasis particularly in the presence of secondary hyperparathyroidism.
KW - Chronic renal failure
KW - Free calcium clamp
KW - Metabolic acidosis
KW - Secondary hyperparathyroidism
UR - http://www.scopus.com/inward/record.url?scp=0028206321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028206321&partnerID=8YFLogxK
M3 - Article
C2 - 7969674
AN - SCOPUS:0028206321
SN - 0028-2766
VL - 67
SP - 419
EP - 424
JO - Experimental Nephrology
JF - Experimental Nephrology
IS - 4
ER -