Quantitative pathology of cutaneous nerve terminal degeneration in the human skin

Hsiung-Fei Chien, T.-J. Tseng, W.-M. Lin, C.-C. Yang, Y.-C. Chang, R.-C. Chen, S.-T. Hsieh

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87 引文 斯高帕斯(Scopus)


Pathological diagnosis of neuropathy has traditionally depended on ultrastructural examinations of nerve biopsy specimens, particularly for sensory neuropathies affecting unmyelinated and small-myelinated nociceptive nerves. These sensory nerves terminate in the epidermis of the skin, and the pathology of neuropathy usually begins from nerve terminals. We investigated the feasibility of diagnosing small-fiber sensory neuropathy by evaluating cutaneous innervation. Skin biopsy specimens of 3-mm in diameter were obtained from the distal leg and the distal forearm of 55 healthy controls and 35 patients with sensory neuropathy. In the healthy controls, conventional intraepidermal nerve fiber densities (IENF densities) as measured using the image analysis system in the distal forearm and in the distal leg were correlated (r=0.55, P
頁(從 - 到)455-461
期刊Acta Neuropathologica
出版狀態已發佈 - 2001


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