摘要
The mRNA level of CDKN2 (p16), retinoblastoma (Rb) and p53 in cancerous and non-cancerous tissue samples were compared using a semi-quantitative reverse-transcription-polymerase chain reaction method. The mean CDKN2 mRNA level of 10 gastric cancer specimens was significantly higher than that of their non-cancerous tissue samples (p=0.039). In contrast, the mRNA levels of Rb and p53 in gastric cancer tissues were both significantly lower than those in their noncancerous tissue samples. Furthermore, both mRNA ratios of Rb/CDKN2 and p53/CDKN2 were significantly decreased in gastric cancer tissues. Therefore, suppression of both Rb and p53 and overexpression of CDKN2 may be associated with the tumorigenesis of gastric cancer.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 249-254 |
| 頁數 | 6 |
| 期刊 | International Journal of Oncology |
| 卷 | 13 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 8月 1 1998 |
| 對外發佈 | 是 |
ASJC Scopus subject areas
- 腫瘤科
- 癌症研究
