Proteotranscriptomics Analysis Reveals Signature Pathways Associated with Colorectal Cancer Progression: a Pilot Study

Hendrick Gao Min Lim, Yang C. Fann, Yuan Chii Gladys Lee

研究成果: 書貢獻/報告類型會議貢獻

摘要

Colorectal cancer is one of the most common cancers in hnmans. Studying proteotranscriptomics data conld be essential to discovering signature pathways in colorectal cancer progression. Herein, we conducted a proteotranscriptomics analysis to identify pathway differences of cancer progression at the transcript and protein levels, each of which was represented by an independent colorectal cancer study containing tumor and adjacent normal samples. As a result, additional information on pathways at the protein level showed signature pathways associated with colorectal cancer progression which might not have been revealed at the transcript level. Information on the focal adhesion pathway related to actin cytoskeletal regulation and cancer pathways was preserved only at the protein level. Meanwhile, an oxidative phosphorylation pathway, that was highly correlated with the neurodegenerative Alzheimer, Huntington, and Parkinson diseases, was preserved at both the transcript and protein levels. This pilot study also suggests that both focal adhesion and oxidative phosphorylation could be potential colorectal cancer therapeutic targets.
原文英語
主出版物標題Proceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022
發行者Institute of Electrical and Electronics Engineers Inc.
頁面225-230
頁數6
ISBN(電子)9781665484879
DOIs
出版狀態已發佈 - 2022
事件22nd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2022 - Virtual, Online, 臺灣
持續時間: 11月 7 202211月 9 2022

出版系列

名字Proceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022

會議

會議22nd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2022
國家/地區臺灣
城市Virtual, Online
期間11/7/2211/9/22

ASJC Scopus subject areas

  • 電腦網路與通信
  • 電腦科學應用
  • 資訊系統
  • 資訊系統與管理
  • 生物醫學工程
  • 數值分析

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