TY - JOUR
T1 - Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma
AU - Chung, Chi Jung
AU - Pu, Yeong Shiau
AU - Chen, Ying Ting
AU - Su, Chien Tien
AU - Wu, Chia Chang
AU - Shiue, Horng Sheng
AU - Huang, Chao Yuan
AU - Hsueh, Yu Mei
PY - 2011/2/15
Y1 - 2011/2/15
N2 - Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.
AB - Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.
KW - 8-OHdG
KW - Plasma micronutrients
KW - Urinary arsenic profiles
KW - Urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=78751704792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751704792&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2010.11.037
DO - 10.1016/j.scitotenv.2010.11.037
M3 - Article
C2 - 21227482
AN - SCOPUS:78751704792
SN - 0048-9697
VL - 409
SP - 1039
EP - 1045
JO - Science of the Total Environment
JF - Science of the Total Environment
IS - 6
ER -