Prolonged injection time and light smoking decrease the incidence of fentanyl-induced cough

Jui An Lin, Chun Chang Yeh, Meei Shyuan Lee, Ching Tang Wu, Shinn Long Lin, Chih Shung Wong

研究成果: 雜誌貢獻文章同行評審

74 引文 斯高帕斯(Scopus)


We designed this study to evaluate the effect of injection time and smoking on fentanyl-induced cough. Four-hundred-fifty ASA class I-II patients, aged 18-80 yr and weighing 40-90 kg, scheduled for elective surgery were included. All patients received fentanyl (100 μg for patients weighing 40-69 kg and 150 μg for patients weighing 70-90 kg for clinical convenience) via the proximal port of a peripheral IV line on the forearm. Patients were randomly assigned to 3 groups of 150 patients each. Patients in Group I received fentanyl injection over 2 s, whereas for patients in Groups II and III the fentanyl was injected at a constant rate over 15 s and 30 s, respectively. We recorded the number of coughs of each patient during and 30 s after fentanyl injection. The incidence of cough was 18% in group I, 8% in Group II, and 1.3% in Group III, significantly less (P < 0.05) with a longer injection time. Current smokers had a less frequent incidence of cough than nonsmokers; however, this effect was only significant in light smokers (<10 cigarettes per day or <10 smoking years or <10 pack-years). In conclusion, a longer injection time reduces the incidence of fentanyl-induced cough, and light smoking may be a protective factor against fentanyl-induced cough.

頁(從 - 到)670-674
期刊Anesthesia and Analgesia
出版狀態已發佈 - 9月 2005

ASJC Scopus subject areas

  • 麻醉與疼痛醫學


深入研究「Prolonged injection time and light smoking decrease the incidence of fentanyl-induced cough」主題。共同形成了獨特的指紋。