Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

Jan Show Chu; Chiun Sheng Huang; King Jen Chang

doi:10.1016/S0304-3835(98)00118-9

Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

Jan Show Chu, Chiun Sheng Huang, King Jen Chang

研究成果: 雜誌貢獻 › 文章 › 同行評審

20 引文斯高帕斯（Scopus）

摘要

To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

原文	英語
頁（從 - 到）	145-152
頁數	8
期刊	Cancer Letters
卷	131
發行號	2
DOIs	https://doi.org/10.1016/S0304-3835(98)00118-9
出版狀態	已發佈 - 9月 25 1998
對外發佈	是

ASJC Scopus subject areas

癌症研究
分子生物學
腫瘤科

UN SDG

此研究成果有助於以下永續發展目標

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10.1016/S0304-3835(98)00118-9

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abstract = "To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P",

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AU - Chang, King Jen

PY - 1998/9/25

Y1 - 1998/9/25

N2 - To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

AB - To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

KW - Breast cancer

KW - Immunohistochemistry

KW - p53

KW - PCNA

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ER -

Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

摘要

ASJC Scopus subject areas

UN SDG

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