Prognostic significance of immunoglobulin and T cell receptor gene rearrangements in patients with acute myeloid leukemia: Taiwan experience

Chueh Chuan Yen, Jin Hwang Liu, Wei Shu Wang, Tzeon Jye Chiou, Frank S. Fan, Po Min Chen

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

We investigated the prognostic significance of lymphoid antigen receptor gene rearrangement in patients with newly diagnosed acute myeloid leukemia (AML). Thirty-nine patients were included in the study. Clonal gene rearrangement of immunoglobulin heavy chain (IgH) and T cell receptor β chain (TCRβ) was found in leukemic cells in 11 (28.2%) and 10 (25.6%) patients, respectively. Five (12.8%) had both IgH and TCRβ gene rearrangements. Three of the seven (42.9%) B-lymphoid marker-positive and eight of the 32 (25%) B-lymphoid marker-negative patients had clonal IgH gene rearrangements. Five of the 11 (45.5%) T-lymphoid marker-positive and 5 of the 28 (17.9%) T-lymphoid marker-negative patients had clonal TCRβ gene rearrangements. All patients were treated with similar regimens. The complete remission rate (62.5% vs 65.2%, p = 1.000) and median survival (13 vs 14 months, p = 0.366) were similar in patients with and without clonal IgH or TCRβ gene rearrangements. In conclusion, while clonal rearrangements of IgH or TCRβ genes were found in AML patients, they did not appear to effect the prognosis.
原文英語
頁(從 - 到)179-187
頁數9
期刊Leukemia and Lymphoma
35
發行號1-2
DOIs
出版狀態已發佈 - 1999
對外發佈

ASJC Scopus subject areas

  • 血液學
  • 腫瘤科
  • 癌症研究

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