Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

Tung Bo Chao, Chien Feng Li, Ching Yih Lin, Yu Feng Tian, I. Wei Chang, Ming Jen Sheu, Ying En Lee, Ti Chun Chan, Hong Lin He

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)


Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
頁(從 - 到)1457-1467
期刊Future Oncology
出版狀態已發佈 - 6月 1 2016

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究


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