Production of therapeutic glycoproteins in glycoengineered plant: old farm for new crops

Mu-Rong Kao, Rebecka Karmarkar Saldivar, Yves S.Y. Hsieh

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Plant-based expression systems have emerged as promising avenues for the production of recombinant N-linked glycoproteins. This review offers insights into the evolution and progress of plant glycoengineering. It delves into the distinctive features of plant-derived N-glycans, the diverse range of plant hosts employed for glycoprotein synthesis, and the advancements in glycoengineering strategies aimed at generating glycoproteins with N-glycan structures akin to those produced in mammalian cell lines. Furthermore, alternative strategies for augmenting glycoengineering efforts and the current spectrum of applications for plant-produced N-glycan recombinant proteins are examined, underscoring their potential significance in biopharmaceutical manufacturing.
原文英語
文章編號103145
期刊Current Opinion in Biotechnology
87
出版狀態已發佈 - 6月 2024

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