TY - JOUR
T1 - Production of Human Interferon-β by Sendai Virus and Poly(rI)-Poly(rC)
T2 - Inhibition by neomycin
AU - Lin, H. Y.
AU - Davis, P. J.
AU - Thacore, H. R.
PY - 1991
Y1 - 1991
N2 - Neomycin inhibits the production of interferon-β (IFN-β) in human fibroblast cells in response to Sendai virus or to poly(rI) · poly(rC) in a concentration-dependent manner, and to the greatest extent effective when added prior to or up to 2 h after induction. This inhibitory effect is negated when the protein kinase C activator, SC-9, is present during IFN-β production in response to poly(rI) · poly(rC), but not in response to Sendai virus. These results suggest that in human cells both virus and poly(rI) · poly(rC) utilize an early neomycin-sensitive signal transduction step for the production of IFN-β; because neomycin binds specific phosphatidylinositol phosphates, both of these inducers very likely require hydrolysis of these phosphates.
AB - Neomycin inhibits the production of interferon-β (IFN-β) in human fibroblast cells in response to Sendai virus or to poly(rI) · poly(rC) in a concentration-dependent manner, and to the greatest extent effective when added prior to or up to 2 h after induction. This inhibitory effect is negated when the protein kinase C activator, SC-9, is present during IFN-β production in response to poly(rI) · poly(rC), but not in response to Sendai virus. These results suggest that in human cells both virus and poly(rI) · poly(rC) utilize an early neomycin-sensitive signal transduction step for the production of IFN-β; because neomycin binds specific phosphatidylinositol phosphates, both of these inducers very likely require hydrolysis of these phosphates.
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M3 - Article
C2 - 1666117
AN - SCOPUS:0026381750
SN - 0197-8357
VL - 11
SP - 365
EP - 369
JO - Journal of Interferon Research
JF - Journal of Interferon Research
IS - 6
ER -