Probing the biological obstacles of nanomedicine with gold nanoparticles

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50 引文 斯高帕斯(Scopus)


Despite massive growth in nanomedicine research to date, the field still lacks fundamental understanding of how certain physical and chemical features of a nanoparticle affect its ability to overcome biological obstacles in vivo and reach its intended target. To gain fundamental understanding of how physical and chemical parameters affect the biological outcomes of administered nanoparticles, model systems that can systematically manipulate a single parameter with minimal influence on others are needed. Gold nanoparticles are particularly good model systems in this case as one can synthetically control the physical dimensions and surface chemistry of the particles independently and with great precision. Additionally, the chemical and physical properties of gold allow particles to be detected and quantified in tissues and cells with high sensitivity. Through systematic biological studies using gold nanoparticles, insights toward rationally designed nanomedicine for in vivo imaging and therapy can be obtained. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
期刊Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
出版狀態已發佈 - 5月 1 2019

ASJC Scopus subject areas

  • 生物工程
  • 醫藥(雜項)
  • 生物醫學工程


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