@article{a47f77ea9c604cf59ea074dadce5a80d,
title = "Preventive effects of fucoidan and fucoxanthin on hyperuricemic rats induced by potassium oxonate",
abstract = "The purpose of this study was to investigate the preventive effects of fucoidan (Fc) and fucoxanthin (Fx) on hyperuricemic rats. Sprague Dawley (SD) rats were randomly assigned to seven groups: a control group, a hyperuricemia (HUA) group, low- and high-dose Fx groups, a Fc group, a combination Fc and Fx group, and a positive control group. Three weeks after the interventions, each group was given potassium oxonate (PO) and hypoxanthine (HX) to induce HUA in all groups except for the control group, and the rats were then sacrificed. Blood and urine were analyzed for biochemical properties, and differences in urine volume were determined. Livers and kidneys were collected to analyze xanthine oxidase (XO) activity and the expression of uric acid (UA) transporter-related proteins (GLUT9, ABCG2, OAT1, URAT1). The results show that HUA was successfully induced by PO/HX after 4 h of administration. The activity of XO was significantly reduced by a combination of Fc and Fx. In the combination group, both ABCG2 and OAT1 increased significantly, whereas GLUT9 and URAT1 decreased significantly. In summary, the combination of Fc and Fx can inhibit the activity of XO in the liver and regulate the expression of proteins related to UA transporter in the kidney to reduce the UA level in serum.",
keywords = "Fucoidan, Fucoxanthin, Hyperuricemia, Uric acid, Xanthine oxidase",
author = "Chau, {Yung Tsung} and Chen, {Hsin Yuan} and Lin, {Po Han} and Hsia, {Shih Min}",
note = "Funding Information: This research was funded by the Ministry of Science and Technology (MOST), Taiwan, Republic of China, under grant numbers MOST106-2320-B-038-064-MY3 and MOST103-2313-B-038-003-MY3, by the Council of Agriculture, Taiwan, Republic of China, under grant numbers 106AS-16.4.1-ST-a4 and 107AS-13.4.1-ST-a6, and by the Council of Agriculture, Taiwan, Republic of China. The authors gratefully acknowledge Dr. Hui-Wen Chang (Taipei Medical University Hospital) for technical support. Miss. Yi-Fen Chiang, Miss. Hui-Chih Hung, and Mr. Ko-Chieh Huang (School of Nutrition and Health Sciences, Taipei Medical University) for animal study support. Funding Information: Funding: This research was funded by the Ministry of Science and Technology (MOST), Taiwan, Republic of China, under grant numbers MOST106-2320-B-038-064-MY3 and MOST103-2313-B-038-003-MY3, by the Council of Agriculture, Taiwan, Republic of China, under grant numbers 106AS-16.4.1-ST-a4 and 107AS-13.4.1-ST-a6, and by the Council of Agriculture, Taiwan, Republic of China. Publisher Copyright: {\textcopyright} 2019 by the authors",
year = "2019",
month = jun,
day = "10",
doi = "10.3390/md17060343",
language = "English",
volume = "17",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}