TY - JOUR
T1 - Prevention of cellular ROS damage by isovitexin and related flavonoids
AU - Lin, Chun-Mao
AU - Chen, Chien-Tsu
AU - Lee, Hsiao Hui
AU - Lin, Jen-Kun
PY - 2002
Y1 - 2002
N2 - The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC
50 value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC
50 values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC
50 value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD
50 >400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress.
AB - The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC
50 value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC
50 values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC
50 value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD
50 >400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress.
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U2 - 10.1055/s-2002-26753
DO - 10.1055/s-2002-26753
M3 - Article
C2 - 11988866
AN - SCOPUS:0036256859
SN - 0032-0943
VL - 68
SP - 365
EP - 367
JO - Planta Medica
JF - Planta Medica
IS - 4
ER -