Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy

De-Chuan Chan; Yao-Chi Liu; Cheng-Jueng Chen; Jyh-Cherng Yu; Heng-Cheng Chu; Fa-Chang Chen; Teng-Wei Chen; Huan-Fa Hsieh; Tzu-Ming Chang; Kuo-Liang Shen

Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy

De-Chuan Chan, Yao-Chi Liu, Cheng-Jueng Chen, Jyh-Cherng Yu, Heng-Cheng Chu, Fa-Chang Chen, Teng-Wei Chen, Huan-Fa Hsieh, Tzu-Ming Chang, Kuo-Liang Shen

研究成果: 雜誌貢獻 › 文章 › 同行評審

28 引文斯高帕斯（Scopus）

摘要

Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P

原文	英語
頁（從 - 到）	4776-4781
頁數	6
期刊	World Journal of Gastroenterology
卷	11
發行號	31
出版狀態	已發佈 - 2005
對外發佈	是

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http://www.scopus.com/inward/record.url?eid=2-s2.0-24044541654&partnerID=40&md5=b60c29854053a8ef8277a708ceb55292

引用此

Chan, D-C., Liu, Y-C., Chen, C-J., Yu, J-C., Chu, H-C., Chen, F-C., Chen, T-W., Hsieh, H-F., Chang, T-M., & Shen, K-L. (2005). Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy. World Journal of Gastroenterology, 11(31), 4776-4781. http://www.scopus.com/inward/record.url?eid=2-s2.0-24044541654&partnerID=40&md5=b60c29854053a8ef8277a708ceb55292

Chan, D-C, Liu, Y-C, Chen, C-J, Yu, J-C, Chu, H-C, Chen, F-C, Chen, T-W, Hsieh, H-F, Chang, T-M & Shen, K-L 2005, 'Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy', World Journal of Gastroenterology, 卷 11, 編號 31, 頁 4776-4781. <http://www.scopus.com/inward/record.url?eid=2-s2.0-24044541654&partnerID=40&md5=b60c29854053a8ef8277a708ceb55292>

@article{16322efd9b2b4bdabc0cc9d8110d2f80,

title = "Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy",

abstract = "Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P",

keywords = "C-reactive protein, Gastric cancer, Intraperitoneal chemotherapy, Metoclopramide, antineoplastic agent, atropine, bupivacaine, C reactive protein, cisatracurium, desflurane, edrophonium, fentanyl, lidocaine, metoclopramide, morphine, narcotic agent, opiate, paracetamol, pethidine, suxamethonium, thiamylal, adult, aged, anastomosis leakage, article, bleeding, cancer chemotherapy, chronic disease, clinical article, clinical trial, controlled clinical trial, controlled study, drug dose regimen, drug efficacy, drug mechanism, drug use, epidural anesthesia, feeding, female, flatulence, gastrectomy, gender, hospitalization, human, ileus, incidence, male, mortality, operation duration, outcomes research, pneumonia, postoperative care, postoperative complication, postoperative pain, prophylaxis, risk assessment, stomach cancer, surgical technique, wound infection, Adult, Aged, Dopamine Antagonists, Electrolytes, Female, Gastrectomy, Humans, Ileus, Male, Middle Aged, Pain, Postoperative, Postoperative Complications, Stomach Neoplasms",

author = "De-Chuan Chan and Yao-Chi Liu and Cheng-Jueng Chen and Jyh-Cherng Yu and Heng-Cheng Chu and Fa-Chang Chen and Teng-Wei Chen and Huan-Fa Hsieh and Tzu-Ming Chang and Kuo-Liang Shen",

note = "被引用次數：12 Export Date: 22 March 2016 CODEN: WJGAF 通訊地址: Chan, D.-C.; Division of General Surgery, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; 電子郵件： chrischan1168@yahoo.com.tw 化學物質/CAS: atropine, 51-55-8, 55-48-1; bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5; C reactive protein, 9007-41-4; cisatracurium, 96946-41-7, 96946-42-8; desflurane, 57041-67-5; edrophonium, 312-48-1; fentanyl, 437-38-7; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; metoclopramide, 12707-59-4, 2576-84-3, 364-62-5, 7232-21-5; morphine, 52-26-6, 57-27-2; opiate, 53663-61-9, 8002-76-4, 8008-60-4; paracetamol, 103-90-2; pethidine, 28097-96-3, 50-13-5, 57-42-1; suxamethonium, 306-40-1, 71-27-2; thiamylal, 337-47-3, 77-27-0; Dopamine Antagonists; Electrolytes; Metoclopramide, 364-62-5 參考文獻: Akoh, J.A., Macintyre, I.M., Improving survival in gastric cancer: Review of 5-year survival rates in English language publications from 1970 (1992) Br. J. Surg., 79, pp. 293-299; Landry, J., Tepper, J.E., Wood, W.C., Moulton, E.O., Koerner, F., Sullinger, J., Patterns of failure following curative resection of gastric carcinoma (1990) Int. J. Radiat. Oncol. Biol. Phys., 19, pp. 1357-1362; Hermans, J., Bonenkamp, J.J., Boon, M.C., Bunt, A.M., Ohyama, S., Sasako, M., Van de Velde, C.J., Adjuvant therapy after curative resection for gastric cancer: Meta-analysis of randomized trials (1993) J. Clin. Oncol., 11, pp. 1441-1447; Hallisay, M.T., Dunn, J.A., Ward, L.C., Allum, W.H., The second British stomach cancer group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: Five-year follow-up (1994) Lancet, 343, pp. 1309-1312; Hall, J.J., Loggie, B.W., Shen, P., Beamer, S., Douglas Case, L., McQuellon, R., Geisinger, K.R., Levine, E.A., Cytoreductive surgery with intra-peritoneal hyperthermic chemotherapy for advanced gastric cancer (2004) J. Gastrointest. Surg., 8, pp. 454-463; Sugarbaker, P.H., Yu, W., Yonemura, Y., Gastrectomy, peritonectomy, and perioperative intra-peritoneal chemotherapy: The evolution of treatment strategies for advanced gastric cancer (2003) Semin. Surg. Oncol., 21, pp. 233-248; Sarnaik, A.A., Sussman, J.J., Ahmad, S.A., Lowy, A.M., Technology of intra-peritoneal chemotherapy administration: A survey of techniques with a review of morbidity and mortality (2003) Surg. Oncol. Clin. N. Am., 12, pp. 849-863; Rossi, C.R., Pilati, P., Mocellin, S., Foletto, M., Ori, C., Innocente, F., Nitti, D., Lise, M., Hyperthermic intra-peritoneal intracoperative chemotherapy for peritoneal carcinomatosis arising from gastric adenocarcinoma (2003) Suppl. Tumori, 2, pp. S54-S57; Fujiwara, Y., Taniguchi, H., Kimura, Y., Takiguchi, S., Yasuda, T., Yano, M., Monden, M., Two advanced gastric cancer patients who showed malignant ileus soon after administration of combination therapy of preoperative intra-peritoneal chemotherapy and gastrectomy (2003) Gan To Kagaku Ryoho, 30, pp. 1614-1617; Livingston, E.H., Passaro Jr., E.P., Postoperative ileus (1990) Dig. Dis. Sci., 35, pp. 121-132; Holte, K., Kehlet, H., Postoperative ileus: A preventable event (2000) Br. J. Surg., 87, pp. 1480-1493; Jenner, P., Marsden, C.D., The substituted benzamides - A novel class of dopamine antagonists (1979) Life Sci., 25, pp. 479-485; Albibi, R., McCallum, R.W., Metoclopramide: Pharmacology and clinical application (1983) Ann. Intern. Med., 98, pp. 86-95; Beani, L., Bianchi, C., Cremer, C., Effects of metoclopramide on isolated guinea pig colon. 1. Peripheral sensitization to acetylcholine (1970) Eur. J. Pharmacol., 12, pp. 220-231; Bonacini, M., Quiason, S., Reynolds, M., Gaddis, M., Pemberton, B., Smith, O., Effect of intravenous erythromycin on post-operative ileus (1993) Am. J. Gastroenterol., 88, pp. 208-211; Heimbach, D.M., Crout, J.R., Treatment of paralytic ileus with adrenergic neuronal blocking drugs (1971) Surgery, 69, pp. 582-587; Furness, J.B., Costa, M., Adynamic ileus, its pathogenesis and treatment (1974) Med. Biol., 52, pp. 82-89; Kreis, M.E., Kasparek, M., Zittel, T.T., Becker, H.D., Jehle, E.C., Neostigmine increases post-operative colonic motility in patients undergoing colorectal surgery (2001) Surgery, 130, pp. 449-456; Jepsen, S., Klaerke, A., Nielsen, P.H., Simonsen, O., Negative effect of Metoclopramide in post-operative adynamic ileus. A prospective, randomized, double blind study (1986) Br. J. Surg., 73, pp. 290-291; Maruyama, K., Okabayashi, K., Kinoshita, T., Progress in gastric cancer surgery in Japan and its limits of radicality (1987) World J. Surg., 11, pp. 418-425; Gastric cancer (1998) Japanese Classification of Gastric Carcinoma, pp. 10-24. , Japanese Gastric Cancer Association. 2nd English ed; Sano, T., Sasako, M., Katai, H., Maruyama, K., Amylase concentration of drainage fluid after total gastrectomy (1997) Br. J. Surg., 84, pp. 1310-1312; Zanon, C., Clara, R., Chiappino, I., Bortolini, M., Cornaglia, S., Simone, P., Bruno, F., Pedani, F., Cytoreductive surgery and intra-peritoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer (2004) World J. Surg., 28, pp. 1040-1045; Yano, M., Yasuda, T., Fujiwara, Y., Takiguchi, S., Miyata, H., Monden, M., Preoperative intra-peritoneal chemotherapy for patients with serosa-infiltrating gastric cancer (2004) Surg. Oncol., 88, pp. 39-43; van der Vange, N., van Goethem, A.R., Zoetmulder, F.A., Kaag, M.M., van de Vaart, P.J., ten Bokkel Huinink, W.W., Beijnen, J.H., Extensive cytoreductive surgery combined with intra-operative intra-peritoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: A feasibility pilot (2000) Eur. J. Surg. Onco., 26, pp. 663-668; Gilly, F.N., Beaujard, A., Glehen, O., Grandclement, E., Caillot, J.L., Francois, Y., Sadeghi-Looyeh, B., Vignal, J., Peritonectomy combined with intra-peritoneal chemohyperthermia in abdominal cancer with peritoneal carcinomatosis: Phase I-II study (1999) Anticancer Res., 19, pp. 2317-2321; Bauer, A.J., Boeckxstaens, G.E., Mechanisms of post-operative ileus (2004) Neurogastroenterol. Motil., 16 (SUPPL. 2), pp. 54-60; Luckey, A., Livingston, E., Tache, Y., Mechanisms and treatment of post-operative ileus (2003) Arch. Surg., 138, pp. 206-214; Barquist, E., Bonaz, B., Martinez, V., Rivier, J., Zinner, M.J., Tache, Y., Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats (1996) Am. J. Physiol., 270, pp. R888-R894; Tache, Y., Monnikes, H., Bonaz, B., Rivier, J., Role of CRF in stress-related alterations of gastric and colonic motor function (1993) Ann. N. Y. Acad. Sci., 697, pp. 233-243; Kalff, J.C., Schraut, W.H., Simmons, R.L., Bauer, A.J., Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus (1998) Ann. Surg., 228, pp. 652-663; Kalff, J.C., Buchholz, B.M., Eskandari, M.K., Hierholzer, C., Schraut, W.H., Simmons, R.L., Bauer, A.J., Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat (1999) Surgery, 126, pp. 498-509; Kalff, J.C., Carlos, T.M., Schraut, W.H., Billiar, T.R., Simmons, R.L., Bauer, A.J., Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate post-operative ileus (1999) Gastroenterology, 117, pp. 378-387; Cannon, W., Murphy, F., The movements of the stomach and intestines in some surgical conditions (1906) Ann. Surg., 43, pp. 512-536; Prasad, M., Matthews, J., Deflating post-operative ileus (1999) Gastroenterology, 117, pp. 489-492; Dou, Y., Gregersen, S., Zhao, J., Zhuang, F., Gregersen, H., Morphometric and biomechanical intestinal remodeling induced by fasting in rats (2002) Dig. Dis. Sci., 47, pp. 1158-1168; Baue, A.E., The role of the gut in the development of multiple organ dysfunction in cardiothoracic patients (1993) Ann. Thorac. Surg., 55, pp. 822-829; Deitch, E.A., Berg, R., Bacterial translocation from the gut: A mechanism of infection (1987) J. Burn Care Rehabil., 8, pp. 475-482; Jooste, C.A., Mustoe, J., Collee, G., Metoclopramide improves gastric motility in critically ill patients (1999) Intensive Care Med., 25, pp. 464-468; MacLaren, R., Intolerance to intragastric enteral nutrition in critically ill patients: Complications and management (2000) Pharmacotherapy, 20, pp. 1486-1498; Liu, S., Carpenter, R.L., Neal, J.M., Epidural anesthesia and analgesia (1995) Anesthesiology, 82, pp. 1474-1506; Carpenter, R.L., Gastrointestinal benefits of regional anesthesia/analgesia (1996) Reg. Anesth., 21, pp. 13-17; Steinbrook, R.A., Epidural anesthesia and gastrointestinal motility (1998) Anesth. Analg., 86, pp. 837-844; Garcia-Olmo, D., Paya, J., Lucas, F.J., Garcia-Olmo, D.C., The effects of the pharmacological manipulation of post-operative intestinal motility on colonic anastomoses. An experimental study in a rat model (1997) Int. J. Colorectal Dis., 12, pp. 73-77; Jansen, M., Fass, J., Tittel, A., Mumme, T., Anurov, M., Titkova, S., Polivoda, M., Schumpelick, V., Influence of post-operative epidural analgesia with bupivacaine on intestinal motility, transit time, and anastomotic healing (2002) World J. Surg., 26, pp. 303-306; Holte, K., Kehlet, H., Epidural analgesia and risk of anastomotic leakage (2001) Reg. Anesth. Pain Med., 26, pp. 111-117; Fotiadis, R.J., Badvie, S., Weston, M.D., Allen-Mersh, T.G., Epidural analgesia in gastrointestinal surgery (2004) Br. J. Surg., 91, pp. 828-841; Chung, H.Y., Yu, W., Reevaluation of routine gastrointestinal decompression after gastrectomy for gastric cancer (2003) Hepatogastroenterology, 50, pp. 1190-1192; Yoo, C.H., Son, B.H., Han, W.K., Pae, W.K., Nasogastric decompression is not necessary in operations for gastric cancer: Prospective randomised trial (2002) Eur. J. Surg., 168, pp. 379-383",

year = "2005",

language = "English",

volume = "11",

pages = "4776--4781",

journal = "World Journal of Gastroenterology",

issn = "1007-9327",

publisher = "WJG Press",

number = "31",

}

TY - JOUR

T1 - Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy

AU - Chan, De-Chuan

AU - Liu, Yao-Chi

AU - Chen, Cheng-Jueng

AU - Yu, Jyh-Cherng

AU - Chu, Heng-Cheng

AU - Chen, Fa-Chang

AU - Chen, Teng-Wei

AU - Hsieh, Huan-Fa

AU - Chang, Tzu-Ming

AU - Shen, Kuo-Liang

N1 - 被引用次數：12 Export Date: 22 March 2016 CODEN: WJGAF 通訊地址: Chan, D.-C.; Division of General Surgery, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; 電子郵件： chrischan1168@yahoo.com.tw 化學物質/CAS: atropine, 51-55-8, 55-48-1; bupivacaine, 18010-40-7, 2180-92-9, 55750-21-5; C reactive protein, 9007-41-4; cisatracurium, 96946-41-7, 96946-42-8; desflurane, 57041-67-5; edrophonium, 312-48-1; fentanyl, 437-38-7; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; metoclopramide, 12707-59-4, 2576-84-3, 364-62-5, 7232-21-5; morphine, 52-26-6, 57-27-2; opiate, 53663-61-9, 8002-76-4, 8008-60-4; paracetamol, 103-90-2; pethidine, 28097-96-3, 50-13-5, 57-42-1; suxamethonium, 306-40-1, 71-27-2; thiamylal, 337-47-3, 77-27-0; Dopamine Antagonists; Electrolytes; Metoclopramide, 364-62-5 參考文獻: Akoh, J.A., Macintyre, I.M., Improving survival in gastric cancer: Review of 5-year survival rates in English language publications from 1970 (1992) Br. J. Surg., 79, pp. 293-299; Landry, J., Tepper, J.E., Wood, W.C., Moulton, E.O., Koerner, F., Sullinger, J., Patterns of failure following curative resection of gastric carcinoma (1990) Int. J. Radiat. Oncol. Biol. Phys., 19, pp. 1357-1362; Hermans, J., Bonenkamp, J.J., Boon, M.C., Bunt, A.M., Ohyama, S., Sasako, M., Van de Velde, C.J., Adjuvant therapy after curative resection for gastric cancer: Meta-analysis of randomized trials (1993) J. Clin. Oncol., 11, pp. 1441-1447; Hallisay, M.T., Dunn, J.A., Ward, L.C., Allum, W.H., The second British stomach cancer group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: Five-year follow-up (1994) Lancet, 343, pp. 1309-1312; Hall, J.J., Loggie, B.W., Shen, P., Beamer, S., Douglas Case, L., McQuellon, R., Geisinger, K.R., Levine, E.A., Cytoreductive surgery with intra-peritoneal hyperthermic chemotherapy for advanced gastric cancer (2004) J. Gastrointest. Surg., 8, pp. 454-463; Sugarbaker, P.H., Yu, W., Yonemura, Y., Gastrectomy, peritonectomy, and perioperative intra-peritoneal chemotherapy: The evolution of treatment strategies for advanced gastric cancer (2003) Semin. Surg. Oncol., 21, pp. 233-248; Sarnaik, A.A., Sussman, J.J., Ahmad, S.A., Lowy, A.M., Technology of intra-peritoneal chemotherapy administration: A survey of techniques with a review of morbidity and mortality (2003) Surg. Oncol. Clin. N. Am., 12, pp. 849-863; Rossi, C.R., Pilati, P., Mocellin, S., Foletto, M., Ori, C., Innocente, F., Nitti, D., Lise, M., Hyperthermic intra-peritoneal intracoperative chemotherapy for peritoneal carcinomatosis arising from gastric adenocarcinoma (2003) Suppl. Tumori, 2, pp. S54-S57; Fujiwara, Y., Taniguchi, H., Kimura, Y., Takiguchi, S., Yasuda, T., Yano, M., Monden, M., Two advanced gastric cancer patients who showed malignant ileus soon after administration of combination therapy of preoperative intra-peritoneal chemotherapy and gastrectomy (2003) Gan To Kagaku Ryoho, 30, pp. 1614-1617; Livingston, E.H., Passaro Jr., E.P., Postoperative ileus (1990) Dig. Dis. Sci., 35, pp. 121-132; Holte, K., Kehlet, H., Postoperative ileus: A preventable event (2000) Br. J. Surg., 87, pp. 1480-1493; Jenner, P., Marsden, C.D., The substituted benzamides - A novel class of dopamine antagonists (1979) Life Sci., 25, pp. 479-485; Albibi, R., McCallum, R.W., Metoclopramide: Pharmacology and clinical application (1983) Ann. Intern. Med., 98, pp. 86-95; Beani, L., Bianchi, C., Cremer, C., Effects of metoclopramide on isolated guinea pig colon. 1. Peripheral sensitization to acetylcholine (1970) Eur. J. Pharmacol., 12, pp. 220-231; Bonacini, M., Quiason, S., Reynolds, M., Gaddis, M., Pemberton, B., Smith, O., Effect of intravenous erythromycin on post-operative ileus (1993) Am. J. Gastroenterol., 88, pp. 208-211; Heimbach, D.M., Crout, J.R., Treatment of paralytic ileus with adrenergic neuronal blocking drugs (1971) Surgery, 69, pp. 582-587; Furness, J.B., Costa, M., Adynamic ileus, its pathogenesis and treatment (1974) Med. Biol., 52, pp. 82-89; Kreis, M.E., Kasparek, M., Zittel, T.T., Becker, H.D., Jehle, E.C., Neostigmine increases post-operative colonic motility in patients undergoing colorectal surgery (2001) Surgery, 130, pp. 449-456; Jepsen, S., Klaerke, A., Nielsen, P.H., Simonsen, O., Negative effect of Metoclopramide in post-operative adynamic ileus. A prospective, randomized, double blind study (1986) Br. J. Surg., 73, pp. 290-291; Maruyama, K., Okabayashi, K., Kinoshita, T., Progress in gastric cancer surgery in Japan and its limits of radicality (1987) World J. Surg., 11, pp. 418-425; Gastric cancer (1998) Japanese Classification of Gastric Carcinoma, pp. 10-24. , Japanese Gastric Cancer Association. 2nd English ed; Sano, T., Sasako, M., Katai, H., Maruyama, K., Amylase concentration of drainage fluid after total gastrectomy (1997) Br. J. Surg., 84, pp. 1310-1312; Zanon, C., Clara, R., Chiappino, I., Bortolini, M., Cornaglia, S., Simone, P., Bruno, F., Pedani, F., Cytoreductive surgery and intra-peritoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer (2004) World J. Surg., 28, pp. 1040-1045; Yano, M., Yasuda, T., Fujiwara, Y., Takiguchi, S., Miyata, H., Monden, M., Preoperative intra-peritoneal chemotherapy for patients with serosa-infiltrating gastric cancer (2004) Surg. Oncol., 88, pp. 39-43; van der Vange, N., van Goethem, A.R., Zoetmulder, F.A., Kaag, M.M., van de Vaart, P.J., ten Bokkel Huinink, W.W., Beijnen, J.H., Extensive cytoreductive surgery combined with intra-operative intra-peritoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: A feasibility pilot (2000) Eur. J. Surg. Onco., 26, pp. 663-668; Gilly, F.N., Beaujard, A., Glehen, O., Grandclement, E., Caillot, J.L., Francois, Y., Sadeghi-Looyeh, B., Vignal, J., Peritonectomy combined with intra-peritoneal chemohyperthermia in abdominal cancer with peritoneal carcinomatosis: Phase I-II study (1999) Anticancer Res., 19, pp. 2317-2321; Bauer, A.J., Boeckxstaens, G.E., Mechanisms of post-operative ileus (2004) Neurogastroenterol. Motil., 16 (SUPPL. 2), pp. 54-60; Luckey, A., Livingston, E., Tache, Y., Mechanisms and treatment of post-operative ileus (2003) Arch. Surg., 138, pp. 206-214; Barquist, E., Bonaz, B., Martinez, V., Rivier, J., Zinner, M.J., Tache, Y., Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats (1996) Am. J. Physiol., 270, pp. R888-R894; Tache, Y., Monnikes, H., Bonaz, B., Rivier, J., Role of CRF in stress-related alterations of gastric and colonic motor function (1993) Ann. N. Y. Acad. Sci., 697, pp. 233-243; Kalff, J.C., Schraut, W.H., Simmons, R.L., Bauer, A.J., Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus (1998) Ann. Surg., 228, pp. 652-663; Kalff, J.C., Buchholz, B.M., Eskandari, M.K., Hierholzer, C., Schraut, W.H., Simmons, R.L., Bauer, A.J., Biphasic response to gut manipulation and temporal correlation of cellular infiltrates and muscle dysfunction in rat (1999) Surgery, 126, pp. 498-509; Kalff, J.C., Carlos, T.M., Schraut, W.H., Billiar, T.R., Simmons, R.L., Bauer, A.J., Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate post-operative ileus (1999) Gastroenterology, 117, pp. 378-387; Cannon, W., Murphy, F., The movements of the stomach and intestines in some surgical conditions (1906) Ann. Surg., 43, pp. 512-536; Prasad, M., Matthews, J., Deflating post-operative ileus (1999) Gastroenterology, 117, pp. 489-492; Dou, Y., Gregersen, S., Zhao, J., Zhuang, F., Gregersen, H., Morphometric and biomechanical intestinal remodeling induced by fasting in rats (2002) Dig. Dis. 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PY - 2005

Y1 - 2005

N2 - Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P

AB - Aim: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC). Methods: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization. Results: Gender, the type of resection, operating time, blood loss, tumor status and amount of narcotics were comparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P = 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C (groups A and C vs group B, P

KW - C-reactive protein

KW - Gastric cancer

KW - Intraperitoneal chemotherapy

KW - Metoclopramide

KW - antineoplastic agent

KW - atropine

KW - bupivacaine

KW - C reactive protein

KW - cisatracurium

KW - desflurane

KW - edrophonium

KW - fentanyl

KW - lidocaine

KW - metoclopramide

KW - morphine

KW - narcotic agent

KW - opiate

KW - paracetamol

KW - pethidine

KW - suxamethonium

KW - thiamylal

KW - adult

KW - aged

KW - anastomosis leakage

KW - article

KW - bleeding

KW - cancer chemotherapy

KW - chronic disease

KW - clinical article

KW - clinical trial

KW - controlled clinical trial

KW - controlled study

KW - drug dose regimen

KW - drug efficacy

KW - drug mechanism

KW - drug use

KW - epidural anesthesia

KW - feeding

KW - female

KW - flatulence

KW - gastrectomy

KW - gender

KW - hospitalization

KW - human

KW - ileus

KW - incidence

KW - male

KW - mortality

KW - operation duration

KW - outcomes research

KW - pneumonia

KW - postoperative care

KW - postoperative complication

KW - postoperative pain

KW - prophylaxis

KW - risk assessment

KW - stomach cancer

KW - surgical technique

KW - wound infection

KW - Adult

KW - Aged

KW - Dopamine Antagonists

KW - Electrolytes

KW - Female

KW - Gastrectomy

KW - Humans

KW - Ileus

KW - Male

KW - Middle Aged

KW - Pain, Postoperative

KW - Postoperative Complications

KW - Stomach Neoplasms

M3 - Article

SN - 1007-9327

VL - 11

SP - 4776

EP - 4781

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 31

ER -

Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy

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