TY - JOUR
T1 - Prevalence of sleep-related breathing disorders and associated risk factors among people with dementia
T2 - A meta-analysis
AU - Aini, Nur
AU - Chu, Hsin
AU - Banda, Kondwani Joseph
AU - Chen, Ruey
AU - Lee, Tso Ying
AU - Pien, Li Chung
AU - Liu, Doresses
AU - Lai, Yueh Jung
AU - Kang, Xiao Linda
AU - Chou, Kuei Ru
N1 - Funding Information:
The findings and conclusions in this document are those of the authors, who are responsible for its contents.
Publisher Copyright:
© 2023
PY - 2023/3
Y1 - 2023/3
N2 - Objective: Sleep-related breathing disorders (SRBD) have shown to cause worsened cognitive impairment among people with dementia. Therefore, we conducted the first meta-analysis to estimate the prevalence of SRBD among people with dementia. Methods: Comprehensive searches were conducted in Embase, Ovid-MEDLINE, PubMed, PsycINFO, Scopus, Web of Science, and CINAHL. The generalized linear mixed model (GLMM) was used for the pooled prevalence analysis and heterogeneity using I2 test and Cochran's Q-statistic in R-software. Study quality was assessed by Hoy's risk of bias assessment tool. Overall, 20 studies from 1282 studies were included with 1461 participants. Results: The pooled prevalence of SRBD among dementia was 59% (95%CI: 44%–73%) with 55% (95%CI: 34%–74%) for obstructive sleep apnea (OSA), 49% (95%CI: 25%–73%) for unspecified SRBD, and 11% (95%CI: 5%–21%) for central sleep apnea (CSA). Regarding dementia subtypes, the prevalence of SRBD was 89% (95%CI: 61%–97%) for Alzheimer's dementia, 56% (95%CI: 48%–63%) for Parkinson's and Idiopathic Parkinson's dementia, and 16% (95%CI: 8%–30%) for Huntington's dementia. Significant moderator variables were male, body mass index, larger waist and hip circumference, waist-hip ratio, and comorbidities including hypertension, dyslipidemia, renal disease, diabetes, heart disease, and stroke. Conclusions: There is considerable high prevalence of SRBD among dementia people, with OSA and unspecified SRBD being fivefold higher than CSA. Regarding dementia subtypes, Parkinson's and Idiopathic Parkinson's, and Alzheimer's dementia had four to sixfold increased risk of presenting with SRBD than Huntington's dementia. Therefore, assessment and management of SRBD in Alzheimer's, and Parkinson's and Idiopathic Parkinson's dementia deserves more attention in future research.
AB - Objective: Sleep-related breathing disorders (SRBD) have shown to cause worsened cognitive impairment among people with dementia. Therefore, we conducted the first meta-analysis to estimate the prevalence of SRBD among people with dementia. Methods: Comprehensive searches were conducted in Embase, Ovid-MEDLINE, PubMed, PsycINFO, Scopus, Web of Science, and CINAHL. The generalized linear mixed model (GLMM) was used for the pooled prevalence analysis and heterogeneity using I2 test and Cochran's Q-statistic in R-software. Study quality was assessed by Hoy's risk of bias assessment tool. Overall, 20 studies from 1282 studies were included with 1461 participants. Results: The pooled prevalence of SRBD among dementia was 59% (95%CI: 44%–73%) with 55% (95%CI: 34%–74%) for obstructive sleep apnea (OSA), 49% (95%CI: 25%–73%) for unspecified SRBD, and 11% (95%CI: 5%–21%) for central sleep apnea (CSA). Regarding dementia subtypes, the prevalence of SRBD was 89% (95%CI: 61%–97%) for Alzheimer's dementia, 56% (95%CI: 48%–63%) for Parkinson's and Idiopathic Parkinson's dementia, and 16% (95%CI: 8%–30%) for Huntington's dementia. Significant moderator variables were male, body mass index, larger waist and hip circumference, waist-hip ratio, and comorbidities including hypertension, dyslipidemia, renal disease, diabetes, heart disease, and stroke. Conclusions: There is considerable high prevalence of SRBD among dementia people, with OSA and unspecified SRBD being fivefold higher than CSA. Regarding dementia subtypes, Parkinson's and Idiopathic Parkinson's, and Alzheimer's dementia had four to sixfold increased risk of presenting with SRBD than Huntington's dementia. Therefore, assessment and management of SRBD in Alzheimer's, and Parkinson's and Idiopathic Parkinson's dementia deserves more attention in future research.
KW - Dementia
KW - Meta-analysis
KW - Prevalence
KW - Sleep-related breathing disorders
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U2 - 10.1016/j.sleep.2023.01.020
DO - 10.1016/j.sleep.2023.01.020
M3 - Article
C2 - 36758347
AN - SCOPUS:85147805905
SN - 1389-9457
VL - 103
SP - 51
EP - 61
JO - Sleep Medicine
JF - Sleep Medicine
ER -