TY - JOUR
T1 - Prevalence of sleep disturbances and their effects on quality of life in adults with untreated pituitary tumor and meningioma
AU - Lin, Mei Ru
AU - Chen, Pin Yuan
AU - Wang, Huan Chih
AU - Lin, Pei Ching
AU - Lee, Hsin Chien
AU - Chiu, Hsiao Yean
N1 - Funding Information:
This study was supported by grants from Chang Gung Memorial Hospital (CMRPG2K0251 and CLRPG2L0051) and the Ministry of Science and Technology, Taiwan (MOST 110-2628-B-038-017).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Purpose: To explore the prevalence of sleep disturbances and their effects on quality of life in adults with pituitary tumor or meningioma. Methods: This prospective study included 33 and 44 patients with pituitary tumor and meningioma, respectively. All participants completed a series of valid questionnaires for assessing sleep and quality of life; all participants wore 3-day actigraph prior to related treatment. The actigraph-derived sleep parameters included total sleep time, sleep onset latency, wake after sleep onset, sleep efficiency, and dichotomy index (I < O) value. Results: The prevalence of insomnia, excessive daytime sleepiness, and poor sleep quality was 46.8%, 6.5%, and 81.8%, respectively. The differences in these sleep parameters between patients with pituitary tumor and those with meningioma were nonsignificant. Only 27 participants completed the actigraphic assessments. The mean I < O value was 95.99%, and nearly 60% participants exhibited circadian rhythm disruption. Sleep quality was the only sleep variable independently correlated with preoperative quality of life, even after adjustments for confounders (B = 0.80, p = 0.02). Conclusions: Insomnia, poor sleep quality, and disrupted circadian rhythm are highly prevalent in adults with untreated pituitary tumor or meningioma. Sleep quality independently correlated with quality of life. We indirectly confirmed that tumor location may not be a possible cause of sleep changes.
AB - Purpose: To explore the prevalence of sleep disturbances and their effects on quality of life in adults with pituitary tumor or meningioma. Methods: This prospective study included 33 and 44 patients with pituitary tumor and meningioma, respectively. All participants completed a series of valid questionnaires for assessing sleep and quality of life; all participants wore 3-day actigraph prior to related treatment. The actigraph-derived sleep parameters included total sleep time, sleep onset latency, wake after sleep onset, sleep efficiency, and dichotomy index (I < O) value. Results: The prevalence of insomnia, excessive daytime sleepiness, and poor sleep quality was 46.8%, 6.5%, and 81.8%, respectively. The differences in these sleep parameters between patients with pituitary tumor and those with meningioma were nonsignificant. Only 27 participants completed the actigraphic assessments. The mean I < O value was 95.99%, and nearly 60% participants exhibited circadian rhythm disruption. Sleep quality was the only sleep variable independently correlated with preoperative quality of life, even after adjustments for confounders (B = 0.80, p = 0.02). Conclusions: Insomnia, poor sleep quality, and disrupted circadian rhythm are highly prevalent in adults with untreated pituitary tumor or meningioma. Sleep quality independently correlated with quality of life. We indirectly confirmed that tumor location may not be a possible cause of sleep changes.
KW - Circadian rhythm
KW - Meningioma
KW - Pituitary tumor
KW - Quality of life
KW - Sleep disturbances
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U2 - 10.1007/s11060-021-03811-w
DO - 10.1007/s11060-021-03811-w
M3 - Article
AN - SCOPUS:85111118836
SN - 0167-594X
VL - 154
SP - 179
EP - 186
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 2
ER -