Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas

Cheng Jeng Tai, Ching Fong Liao, Tzu Cheng Su, Ko Hung Shen, Chun Chao Chang, Shu Hui Lin, Chung Min Yeh, Shing Chuan Shen, Woan Ruoh Lee, Jeng Fong Chiou, Chih Hung Lin, Ying Chun Chen, Hsin Yi Shih, Kun Tu Yeh, Ming Chung Jiang

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p
原文英語
頁(從 - 到)e280-e284
期刊International Journal of Biological Markers
27
發行號3
DOIs
出版狀態已發佈 - 7月 2012

ASJC Scopus subject areas

  • 病理學與法醫學
  • 腫瘤科
  • 臨床生物化學
  • 癌症研究

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