摘要
Seven diarylheptylamine (12a-g) and four diarylheptanoid analogs (3-5, 9), structurally related to the natural anti-inflammatory agent oregonin (1), have been prepared from curcumin (2) for evaluation of their activity against the expression of iNOS and COX-2. Diarylheptylamine 12b and diarylheptanoid analogs can inhibit iNOS and COX-2 responses of LPS, although less potently than 1. These compounds, however, possess stronger potency than 1 against COX-2-derived PGE2 formation, of which hexahydrocurcumin (4) is the most potent one with an IC50 value of 0.7 μM.
原文 | 英語 |
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頁(從 - 到) | 6175-6181 |
頁數 | 7 |
期刊 | Bioorganic and Medicinal Chemistry |
卷 | 13 |
發行號 | 22 |
DOIs | |
出版狀態 | 已發佈 - 11月 15 2005 |
ASJC Scopus subject areas
- 生物化學
- 分子醫學
- 分子生物學
- 藥學科學
- 藥物發現
- 臨床生物化學
- 有機化學