@article{bd737d946b1f43238baa7fd98f8f3f2c,
title = "Precordial t-wave inversions in patients with arrhythmogenic right ventricular cardiomyopathy who present with the initial features of right ventricular outflow tract arrhythmia",
abstract = "Background: Precordial T-wave inversion (TWI) is an important diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC). Objective: This study aimed to characterize the initial repolarization features of definite ARVC in patients who first presented with right ventricular outflow tract ventricular arrhythmia (RVOT-VA) and TWI. Methods: Patients who presented with RVOT-VA and TWI ≥ V2 were retrospectively assessed. The initial characteristics of repolarization between patients with and without a final diagnosis of definite ARVC during follow-up were compared. Results: TWI ≥ V2 was observed in 61 of 553 patients (mean age: 44.1 ± 14.7 years; 14 men) with RVOT-VAs. After an average follow-up time of 54.9 ± 33.7 months, 31 (50.8%) patients were classified into the definite ARVC group and 30 (49.2%) into the non-definite ARVC group. The disappearance of precordial TWI ≥ V2 was observed in eight (13.1%) patients after the elimination of RVOT-VAs. In a multivariate analysis of the initial electrocardiogram features, only fragmented QRS [odds ratio (OR): 15.45, 95% confidence interval (CI): 1.61-148.26, p = 0.02] and precordial V2 TpTe interval (OR: 1.03, 95% CI: 1.01-1.06, p = 0.02) could independently predict definite ARVC during longitudinal follow-up. An initial V2 TpTe cutoff value > 88.5 ms could predict the final diagnosis of definite ARVC, with a sensitivity and specificity of 74.2% and 78.6%, respectively. Conclusions: Despite the high risk of ARVC in RVOT-VAs and TWI ≥ V2, “normalization” of TWI was observed after ventricular arrhythmia elimination in 13.1% of the patients. Fragmented QRS and longer V2 TpTe interval were associated with definite ARVC during longitudinal follow-up.",
keywords = "Arrhythmogenic right ventricular cardiomyopathy, Radiofrequency catheter ablation, Right ventricular outflow tract arrhythmia, T-wave inversion, Tpeak-Tend interval",
author = "Chung, {Fa Po} and Wu, {Cheng I.} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Lin, {Chin Yu} and Chang, {Ting Yung} and Chao, {Tze Fan} and Liao, {Jo Nan} and Tuan, {Ta Chuan} and Ling Kuo and Liu, {Chih Min} and Chin, {Chye Gen} and Liao, {Ying Chieh} and Chen, {Shih Ann}",
note = "Funding Information: 061-MY2, MOST 106-2314-B-075-006-MY3, MOST 106-2314-B-010-046-MY3, and MOST 106-2314-B-075-073-MY3), Research Foundation of Cardiovascular Medicine, Szu-Yuan Research Foundation of Internal Medicine, and Taipei Veterans General Hospital (grant nos. V106C-158, V106B-010, V106C-104, V107B-014, V107C-060, and V107C-054). Funding Information: This work was supported by the Center for Dynamical Biomarkers and Translational Medicine, Ministry of Science and Technology (grant nos. 107-2314-B-010- Funding Information: This work was supported by the Center for Dynami-cal Biomarkers and Translational Medicine, Ministry of Science and Technology (grant nos. 107-2314-B-010-061-MY2, MOST 106-2314-B-075-006-MY3, MOST 106-2314-B-010-046-MY3, and MOST 106-2314-B-075-073-MY3), Research Foundation of Cardiovascular Medicine, Szu-Yuan Research Foundation of Internal Medicine, and Taipei Veterans General Hospital (grant nos. V106C-158, V106B-010, V106C-104, V107B-014, V107C-060, and V107C-054). Publisher Copyright: {\textcopyright} 2020, Republic of China Society of Cardiology. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.6515/ACS.202009_36(5).20200621A",
language = "English",
volume = "36",
pages = "464--474",
journal = "Acta Cardiologica Sinica",
issn = "1011-6842",
publisher = "Republic of China Society of Cardiology",
number = "5",
}