Pre-dialytic spo2 measured with a wearable device as a predictor of mortality in patients with osa and chronic kidney disease

Hsiao Wei Lu, Pin Hung Kuo, Cheuk Sing Choy, Chih Yu Hsieh, Jia Feng Chang, Mai Szu Wu, Jing Quan Zheng, Jian Chiun Liou

研究成果: 雜誌貢獻文章同行評審

摘要

Hypoxemia and obstructive sleep apnea (OSA) have been recognized as a threat to life. Nonetheless, information regarding the association between pre-dialytic pulse oximeter saturation (SpO2) level, OSA and mortality risks remains mysterious in patients with maintenance hemodialysis (MHD). Bioclinical characteristics and laboratory features were recorded at baseline. Pre-dialytic SpO2 was detected using a novel microchip LED oximetry, and the Epworth Sleepiness Scale (ESS) score greater than 10 indicated OSA. Non-adjusted and adjusted hazard ratios (aHRs) of all-cause and cardiovascular (CV) mortality were analyzed for pre-dialytic SpO2, OSA and potential risk factors. During 2152.8 patient-months of follow-up, SpO2 was associated with incremental risks of all-cause and CV death (HR: 0.90 (95% CI: 0.82–0.98) and 0.88 (95% CI: 0.80–0.98), respectively). The association between OSA and CV mortality was significant (HR: 3.19 (95% CI: 1.19–9.38). In the multivariate regression analysis, pre-dialytic SpO2 still had an increase in all-cause and CV death risk (HR: 0.88 (95% CI: 0.79–0.98), 0.82 (95% CI: 0.71–0.96), respectively). Considering the high prevalence of silent hypoxia in the post COVID-19 era, a lower pre-dialytic SpO2 level and severe OSA warn clinicians to assess potential CV risks. In light of clinical accessibility, the microchip LED oximetry could be developed as a wearable device within smartphone technologies and used as a routine screen tool for patient safety in the medical system.
原文英語
文章編號10674
期刊Applied Sciences (Switzerland)
11
發行號22
DOIs
出版狀態已發佈 - 11月 1 2021

ASJC Scopus subject areas

  • 一般材料科學
  • 儀器
  • 一般工程
  • 製程化學與技術
  • 電腦科學應用
  • 流體流動和轉移過程

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