摘要
Background: Curcumin is a polyphenol natural product of the plant Curcuma longa. Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment. Purpose: We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model. Study Design: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice. Methods: The novel object recognition test was used to analyze the recognition memory function. The long-term potentiation was studied using electrophysiological analysis. Western blotting was used to assess the protein expression and activation status. Results: Recognition memory deficit began as early as 4 weeks of age in both male and female Tsc2+/− mice. Oral administration with SLCP activates AMPK activity and inhibits mTOR activity in the brain tissue of Tsc2+/− mice, and can rescue the electrophysiological abnormality and object recognition memory loss in the mice. Conclusions: Our results suggest that SLCP could be an effective treatment for TSC patients.
原文 | 英語 |
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頁(從 - 到) | 132-139 |
頁數 | 8 |
期刊 | Phytomedicine |
卷 | 54 |
DOIs | |
出版狀態 | 已發佈 - 2月 15 2019 |
Keywords
- Curcumin
- Solid lipid curcumin particle
- Tuberous sclerosis complex
ASJC Scopus subject areas
- 分子醫學
- 藥理
- 藥學科學
- 藥物發現
- 補充和替代醫學