Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract

Ming Fang Wu, Hsu Feng Lu, Yu Ming Hsu, Ming Chu Tang, Hsueh Chin Chen, Ching Sung Lee, Yi Yuan Yang, Ming Yang Yeh, Hsiung Kwang Chung, Yi Ping Huang, Chih Chung Wu, Jing Gung Chung

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Agaricus blazei Murill extract (ABM) has been reported to possess antitumor effects. In this study, the role of ABM in tumor growth and metastasis in vivo was evaluated in experimental Smmu 7721 hepatoma cells in severe combined immunodeficiency (SCID) mice and B16F10 melanoma cells lung metastasis in C57BL/6 mice. For the tumor growth model, the size of the liver tumor mass was about 10 mm to 20 mm in the control group. In comparison with the control group, the tumor mass seem to grow slowly with ABM treatment, especially at the high dose. For the tumor metastasis model, after a six-week treatment, the survival rates of B6 mice were 0%, 30%, 10% and 50% for control group, low, median and high concentration ABM treatment groups, respectively. The survival rate showed that pretreatment of C57BL/6 (B6) mice with ABM lengthened their lifespan after tumor cell inoculation, which supports the notion that ABM successfully reduced lung metastasis formation by B16F10 melanoma cells. The treatment effect was dependent on the concentration of ABM for tumor growth and metastasis in these models.

原文英語
頁(從 - 到)399-404
頁數6
期刊In Vivo
25
發行號3
出版狀態已發佈 - 2011

ASJC Scopus subject areas

  • 一般生物化學,遺傳學和分子生物學
  • 癌症研究
  • 藥理

指紋

深入研究「Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract」主題。共同形成了獨特的指紋。

引用此