Polyunsaturated fatty acid deficit in patients with bipolar mania

Chih Chiang Chiu, Shih Yi Huang, Kuan Pin Su, Mong Liang Lu, Ming Chyi Huang, Chiao Chicy Chen, Winston W. Shen

研究成果: 雜誌貢獻文章同行評審

134 引文 斯高帕斯(Scopus)


The aim of this study is to test the hypothesis that there is a depletion of polyunsaturated fatty acids of erythrocyte membranes in patients with bipolar disorder and to connect the previous therapeutic and psychoimmunological findings. Fatty acid compositions of erythrocyte membranes in 20 bipolar manic patients and 20 healthy controls were analyzed by thin-layer chromatography and gas chromatography. The major finding was significantly reduced arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) compositions in bipolar patients as compared to normal controls with P values of 0.000 and 0.002, respectively. There were no differences in total omega-3 and omega-6 polyunsaturated fatty acids. This abnormality may be related to the mechanisms of action of mood stabilizers and the previous findings on the abnormal psychoimmunology of patients with bipolar disorder. Larger sample sizes of medicated patients or drug-free manic, well-controlled designs on the diet and smoking, and fatty acid composition measurements during full remission after the index episode are warranted in future studies.
頁(從 - 到)99-103
期刊European Neuropsychopharmacology
出版狀態已發佈 - 3月 2003

ASJC Scopus subject areas

  • 藥理
  • 神經內科
  • 神經病學(臨床)
  • 精神病學和心理健康
  • 生物精神病學
  • 藥學(醫學)


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